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Physics of our days


Subject of study — the aging brain

,
Institute for Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya str. 3, Pushchino, Moscow Region, 142290, Russian Federation

Progress in research aimed at combating neurodegenerative diseases requires a systematic biophysical analysis. It has been shown that the efficiency of cleaning the brain of metabolic and informational 'toxins' depends on the thresholds of excitation of neural networks and waves of 'pollution and purification' propagating inside the brain. This process affects the increase in the characteristic time of the normal functioning of the brain and, consequently, in human life expectancy.

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Fulltext is also available at DOI: 10.3367/UFNe.2020.06.038791
Keywords: neurodegenerative diseases, biological rhythms, sleep, mathematical modeling, wave processes, dynamic stability of life
PACS: 87.18.−h, 87.19.L−, 87.19.xt (all)
DOI: 10.3367/UFNe.2020.06.038791
URL: https://ufn.ru/en/articles/2020/11/c/
000613920600003
2-s2.0-85101555979
2020PhyU...63.1092I
Citation: Ivanitskii G R, Morozov A A "Subject of study — the aging brain" Phys. Usp. 63 1092–1113 (2020)
BibTexBibNote ® (generic)BibNote ® (RIS)MedlineRefWorks

Received: 16th, March 2020, revised: 10th, June 2020, 13th, June 2020

Оригинал: Иваницкий Г Р, Морозов А А «Объект исследования — стареющий мозг» УФН 190 1165–1188 (2020); DOI: 10.3367/UFNr.2020.06.038791

References (119) ↓ Cited by (4) Similar articles (7)

  1. Cummings J et al Alzheimers Dement New York 4 195 (2018)
  2. Cummings J, Ritter A, Zhong K J. Alzheimer’s Disease 64 (s1) S3 (2018)
  3. Nedergaard M Science 263 1768 (1994)
  4. Xie L et al Science 342 373 (2013)
  5. Castillo X et al Front. Neurosci. 131 728 (2019)
  6. A reimagined research strategy for aging, SENS Research Foundation, 18 November 2012, https://www.sens.org/our-research/intro-to-sens-research/
  7. Ivanitsky G R et al Sov. Sci. Rev. D 2 279 (1981); Khizhnyak E P Biofizika 31 897 (1986)
  8. Ivanitskii G R, Medvinskii A B, Tsyganov M A Usp. Fiz. Nauk 164 1041 (1994); Ivanitskii G R, Medvinskii A B, Tsyganov M A Phys. Usp. 37 961 (1994)
  9. Tsyganov M A, Ivanitsky G R, Zemskov E R Phys. Rev. E 89 052907 (2014)
  10. Fry S, Lloyd J, Mitchinson J The Book Of General Ignorance (London: Faber and Faber, 2006); Per. na russk. yaz., Frai S, Lloid Dzh, Mitchinson Dzh Kniga Vseobshchikh Zabluzhdenii (M.: Fantom Press, 2008)
  11. Brockman J (Ed.) What We Believe But Cannot Prove. Today’s Leading Thinkers On Science In The Age Of Certainty (New York: Harper Perennial, 2006); Per. na russk. yaz., Brokman Dzh (Red.) Vo chto My Verim, no Ne Mozhem Dokazat’. Intellektualy XXI Veka o Sovremennoi Nauke (M.: ANF, 2018)
  12. Thorpy M J (Chairman) International Classification of Sleep Disorders: Diagnostic and Coding Manual. Diagnostic Classification Steereing Committee (Rochester, MN: American Sleep Disorders Association, 1990)
  13. Bongard M M Problema Uznavaniya (M.: Nauka, 1967); Per. na angl. yaz., Bongard M Pattern Recognition (New York: Spartan Books, 1970)
  14. "Ekonomo Konstantin" Bol’shaya Sovetskaya Entsiklopediya. V 30 T. (Gl. red. A M Prokhorov) 3-e izd. (M.: Sovetskaya entsiklopediya, 1969-1978)
  15. von Bertalanffy L Science 111 23 (1950)
  16. Morozov A Yu Usp. Fiz. Nauk 162 (8) 83 (1992); Morozov A Yu Sov. Phys. Usp. 35 671 (1992)
  17. Ivanitskii G R, Gartshtein V P Metodologicheskie i Teoreticheskie Problemy Biofiziki (Otv. red. G R Ivanitskii) (M.: Nauka, 1979) p. 190
  18. Ivanitskii G R Usp. Fiz. Nauk 187 757 (2017); Ivanitskii G R Phys. Usp. 60 705 (2017)
  19. "Money and the reticular formation" February 12, 2014. On Psychology and Neuroscience, https://psychneuro.wordpress.com/2014/02/21/money-the-reticular-formation
  20. Bringmann H Genetics 208 1279 (2018)
  21. Koval’zon V M Osnovy Somnologii: Fiziologiya i Neirokhimiya Tsikla "bodrstvovanie - Son" (M.: BINOM. Laboratoriya znanii, 2011)
  22. "Nauchnaya sessiya Otdeleniya fizicheskikh nauk Rossiiskoi akademii nauk "Metody kolebatel’no-volnovoi fiziki v zadachakh i prilozheniyakh neironauki" (31 oktyabrya 2007 g.)" Usp. Fiz. Nauk 178 313 (2008); "Scientific session of the Physical Sciences Division of the Russian Academy of Sciences "Methods of wave-based physics in neuroscience problems and applications" (31 October 2007)" Phys. Usp. 51 295 (2008)
  23. Klin’shov V V, Nekorkin V I Usp. Fiz. Nauk 183 1323 (2013); Klinshov V V, Nekorkin V I Phys. Usp. 56 1217 (2013)
  24. Kazanovich Ya B "Ostsillyatornye neirosetevye modeli kognitivnykh funktsii mozga" Diss. ... dokt. fiz.-mat. nauk (Pushchino: ITEB RAN, 2018)
  25. Kuramoto Y Chemical Oscillations, Waves, And Turbulence (Berlin: Springer-Verlag, 1984)
  26. Kuramoto Y Intern. Symp. On Mathematical Problems In Theoretical Physics (Lecture Notes in Physics) Vol. 39 (Ed. H Araki) (Berlin: Springer, 1975) p. 420
  27. Sakaguchi H, Kuramoto Y Prog. Theor. Phys. 76 576 (1986)
  28. Kazanovich Ya, Borisyuk R Prog. Theor. Phys. 110 1047 (2003)
  29. Borisyuk R M, Kazanovich Ya B Neural Networks 17 899 (2004)
  30. Walter W G The Living Brain (New York: W.W. Norton, 1963); Per. na russk. yaz., Uolter G Zhivoi Mozg (M.: Mir, 1966)
  31. Bushey D, Tononi G, Cirelli C Science 332 1576 (2011)
  32. Diekelmann S, Born J Nat. Rev. Neurosci. 11 114 (2010)
  33. Youngstedt S D, Kripke D F Sleep Med. Rev. 8 159 (2004)
  34. Cirelli C, Tononi G PLOS Biol. 6 1605 (2008)
  35. Vyazovskiy V V et al Nature 472 443 (2011)
  36. Hablitz L M et al Sci. Adv. 5 eaav5447 (2019)
  37. Xie L et al Science 342 373 (2013)
  38. Mestre H et al Clin. Sci. 131 2257 (2017)
  39. Rodriguez A V et al J. Neurosci. 36 12436 (2016)
  40. de Vivo L et al Science 355 507 (2017)
  41. Iadecola C, Nedergaard M Nat. Neurosci. 10 1369 (2007)
  42. Ballabh P, Braun A, Nedergaard M Neurobiol. Disease 16 1 (2004)
  43. Takano T et al Nat. Neurosci. 9 260 (2006)
  44. Kang J et al Nat. Neurosci. 1 683 (1998)
  45. Tian G-F et al Nat. Med. 11 973 (2005)
  46. Ru-Ronga J, Temugina B, Maiken N Pain 154 S10 (2013)
  47. Konnikova M "Goodnight. Sleep clean" New York Times, Jan. 11 (2014)
  48. Asti A, Gioglio L J. Alzheimer’s Disease 39 169 (2014)
  49. Trevaskis N L, Kaminskas L M, Porter C J H Nat. Rev. Drug Discovery 14 781 (2015)
  50. Yurishchev E P i dr Bol’shaya Meditsinskaya Entsiklopediya. V 30 T. Vol. 27 (Gl. red. B V Petrovskii) 3-e izd. (M.: Sovetskaya entsiklopediya, 1986)
  51. Jessen N A et al Neurochem. Res. 40 2583 (2015)
  52. Mestre H et al ELife 7 e40070 (2018)
  53. Plog B A, Nedergaard M Annu. Rev. Pathol. Mech. Disease 13 379 (2018)
  54. DiNuzzo M, Nedergaard M Curr. Opin. Neurobiol. 47 65 (2017)
  55. Crous-Bou M et al Alzheimer’s Res. Therapy 9 71 (2017)
  56. Ashby W R Design For A Brain; The Origin Of Adaptive Behavior (New York: Wiley, 1960); Per. na russk. yaz., Eshbi U R Konstruktsiya Mozga. Proiskhozhdenie Adaptivnogo Povedeniya (M.: IL, 1962)
  57. Hsu D, Marshall G A Curr. Alzheimer Res. 14 426 (2017)
  58. Klein P, Tyrlikova I Epilepsy Behavior 72 188 (2017)
  59. Kosenko E A Zagadka Aloiza Al’tsgeimera. Pochemu v XXI Veke Bolezn’ Al’tsgeimera Neizlechima? (M.: Nauka, 2019)
  60. The Brainstorm Consortium, Anttila V et al Science 360 eaap8757 (2018)
  61. Gitler A D, Dhillon P, Shorter J Disease Models Mech. 10 499 (2017)
  62. Dawson T M, Golde T E, Lagier-Tourenne C Nat. Neurosci. 21 1370 (2018)
  63. Van der Worp H B et al PLoS Med. 7 1000245 (2010)
  64. Mergenthaler P, Meisel A Disease Models Mech. 5 718 (2012)
  65. Abud E M et al Neuron. 94 278 (2017)
  66. Korhonen P, Malm T, White A R Neurochem. Int. 120 191 (2018)
  67. Xie N, Tang B Stem Cells Int. 2016 6484713 (2016)
  68. Robbins J P, Price J Psychol. Med. 47 2587 (2017)
  69. Itakura E et al J. Cell Biol. 219 e201911126 (2020)
  70. Ransohoff R M J. Exp. Med. 215 2955 (2018)
  71. Lee S H, Yoon H-J Kidney Res. Clin. Pract. 36 (1) 3 (2017)
  72. Stepanov A et al PLoS One 13 e0192519 (2018)
  73. Dalle Pezze P et al PLoS Comput. Biol. 10 e003728 (2014)
  74. Lloret-Villas A et al CPT Pharmacometrics Syst. Pharmacol. 6 73 (2017)
  75. Bilgel M, Jedynak V M Alzheimers Dement 11 205 (2019)
  76. Pederson J G Int. Stat. Rev. 46 147 (1978)
  77. Bayes T, Price R Philos. Trans. R. Soc. Lond. 53 370 (1763)
  78. Kahneman D, Slovic P, Tversky A Judgment Under Uncertainty: Heuristics And Biases (Cambridge: Cambridge Univ. Press, 1982); Per. na russk. yaz., Kaneman D, Slovik P, Tverski A Prinyatie Reshenii v Neopredelennosti: Pravila i Predubezhdeniya (Khar’kov: Gumanitarnyi tsentr, 2005)
  79. Becker B G, Klein T, Wachinger C NeuroImage 175 246 (2018)
  80. Davtyan H et at. Alzheimer’s Res. Therapy 11 107 (2019)
  81. Lamb M J Biology Of Ageing (Glasgow: Blackie, 1977); Per. na russk. yaz., Lemb M Biologiya Stareniya (M.: Mir, 1980)
  82. Warner H et al EMBO Rep. 6 1006 (2005)
  83. Tuckwell H C Science 205 493 (1979)
  84. FitzHugh R Biophys. J. 1 445 (1961)
  85. Nagumo J, Arimoto S, Yoshizawa S Proc. IRE 50 2061 (1962)
  86. Van der Pol B, Van der Mark J Nature 120 363 (1927)
  87. Ivanitskii G R, Krinskii V I, Sel’kov E E Matematicheskaya Biofizika Kletki (M.: Nauka, 1978)
  88. Krinskii V I, Mikhailov A S Avtovolny (Ser. Fizika , Vyp. 10) (M.: Znanie, 1984)
  89. Daison F Usp. Fiz. Nauk 180 859 (2010); Dyson F Phys. Usp. 53 825 (2010)
  90. Aschoff J (Ed.) Biological Rhythms (New York: Plenum Press, 1981); Per. na russk. yaz., Ashoff Yu (Red.) Biologicheskie Ritmy (M.: Mir, 1984)
  91. Winfree A T The Timing Of Biological Clocks (New York: Scientific American Library, 1987); Per. na russk. yaz., Uinfri A T Vremya Po Biologicheskim Chasam (M.: Mir, 1990)
  92. Ivanitskii G R, Medvinskii A B, Tsyganov M A Usp. Fiz. Nauk 161 (4) 13 (1991); Ivanitskii G R, Medvinskii A B, Tsyganov M A Sov. Phys. Usp. 34 289 (1991)
  93. Kosek J, Marek M Rev. Lett. 74 2134 (1995)
  94. Petrov V, Scott S K, Showalter K Philos. Trans. R. Soc. Lond. A 347 631 (1994)
  95. Kobayashi R, Ohta T, Hayase Y Phys. Rev. 50 R3291 (1994)
  96. Aslanidi O V, Mornev O A Pis’ma ZhETF 65 553 (1997); Aslanidi O V, Mornev O A JETP Lett. 65 579 (1997)
  97. Aslanidi O V, Mornev O A J. Biol. Phys. 25 149 (1999)
  98. Coullet P et al Phys. Rev. Lett. 65 1352 (1990)
  99. Hagberg A, Meron E Nonlinearity 7 805 (1994)
  100. Malomed B A, Nepomnyashchy A A Europhys. Lett. 27 649 (1994)
  101. Mikhailov A S, Showalter K Phys. Rep. 425 79 (2006)
  102. Ohta T, Kiyose J J. Phys. Soc. Jpn. 65 1967 (1996)
  103. Ohta T, Kiyose J, Mimura M J. Phys. Soc. Jpn. 66 1551 (1997)
  104. Sheintuch M, Nekhamkina O Phys. Rev. E 63 056120 (2001)
  105. Tsyganov M A et al Phys. Rev. Lett. 91 218102 (2003)
  106. Tsyganov M A i dr Usp. Fiz. Nauk 177 275 (2007); Tsyganov M A et al Phys. Usp. 50 263 (2007)
  107. Rinzel J, Keller J B Biophys. J. 13 1313 (1973)
  108. Tonnelier A, Gerstner W Phys. Rev. E 67 021908 (2003)
  109. Arnol’d V I, Varchenko A N, Gusein-Zade S M Osobennosti Differentsiruemykh Otobrazhenii Vol. 1, 2 (M.: Nauka, 1982, 1982, 1984); Per. na angl. yaz., Arnold V I, Gusein-Zade S M, Varchenko A N Singularities Of Differentiable Maps Vol. 1, 2 (Boston: Birkhäuser, 1985, 1988)
  110. Arnol’d V I Teoriya Katastrof 3-e izd. (M.: Nauka, 1990); Per. na angl. yaz., Arnold V I Catastrophe Theory (Berlin: Springer-Verlag, 1992)
  111. Doronina-Amitonova L V i dr Usp. Fiz. Nauk 185 371 (2015); Doronina-Amitonova L V et al Phys. Usp. 58 345 (2015)
  112. Zheltikov A M Usp. Fiz. Nauk 188 1119 (2018); Zheltikov A M Phys. Usp. 61 1016 (2018)
  113. Zheltikov A M, Skalli M O Usp. Fiz. Nauk 190 749 (2020); Zheltikov A M, Scully M O Phys. Usp. 63 698 (2020)
  114. Blanke O et al Brain 127 243 (2004)
  115. Ivanitskii G R Biofizika 44 965 (1999); Ivanitsky G R Biophysics 44 931 (1999)
  116. Ivanitskii G R Usp. Fiz. Nauk 189 759 (2019); Ivanitskii G R Phys. Usp. 62 711 (2019)
  117. Usenko L V, Kligunenko E N, Doronin A G Perftoruglerodnye Aktivnye Sredy dlya Meditsiny i Biologii: Novye Aspekty Issledovaniya (Pod red. G R Ivanitskogo, S I Vorob’eva) (Pushchino: Pushchinskii nauchnyi tsentr biologicheskikh issledovanii, 1993) p. 47
  118. Romodanov A P i dr Perftoruglerodnye Aktivnye Sredy dlya Meditsiny i Biologii: Novye Aspekty Issledovaniya (Pod red. G R Ivanitskogo, S I Vorob’eva) (Pushchino: Pushchinskii nauchnyi tsentr biologicheskikh issledovanii, 1993) p. 63
  119. Usenko L V, Kligunenko E N Fiziologicheskaya Aktivnost’ Ftorsoderzhashchikh Soedinenii: Eksperiment i Klinika (Pod red. G R Ivanitskogo, S I Vorob’eva) (Pushchino: Pushchinskii nauchnyi tsentr biologicheskikh issledovanii, 1995) p. 173
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