Progress in research aimed at combating neurodegenerative diseases requires a systematic biophysical analysis. It has been shown that the efficiency of cleaning the brain of metabolic and informational 'toxins' depends on the thresholds of excitation of neural networks and waves of 'pollution and purification' propagating inside the brain. This process affects the increase in the characteristic time of the normal functioning of the brain and, consequently, in human life expectancy.

Keywords: neurodegenerative diseases, biological rhythms, sleep, mathematical modeling, wave processes, dynamic stability of life PACS: 87.18.−h, 87.19.L−, 87.19.xt (all) DOI: 10.3367/UFNe.2020.06.038791 URL: https://ufn.ru/en/articles/2020/11/c/ 000613920600003 2-s2.0-85101555979 2020PhyU...63.1092I Citation: Ivanitskii G R, Morozov A A "Subject of study — the aging brain" Phys. Usp. 63 1092–1113 (2020) BibTexBibNote ® (generic)BibNote ® (RIS)MedlineRefWorks Received: 16th, March 2020, revised: 10th, June 2020, accepted: 13th, June 2020 Оригинал: Иваницкий Г Р, Морозов А А «Объект исследования — стареющий мозг» УФН 190 1165–1188 (2020); DOI: 10.3367/UFNr.2020.06.038791