Neurophotonics: optical methods to study and control the brain

L.V. Doronina-Amitonova^a, b, I.V. Fedotov^a, b, A.B. Fedotov^a, b, K.V. Anokhin^c, A.M. Zheltikov^{d, a, c, b, e}
^aLomonosov Moscow State University, Vorobevy Gory, Moscow, 119991, Russian Federation
^bInternational Center for Quantum Optics and Quantum Technologies (the Russian Quantum Center), ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russian Federation
^cNational Research Centre ‘Kurchatov Institute’, pl. akad. Kurchatova 1, Moscow, 123182, Russian Federation
^dInternational Laser Center of M.V. Lomonosov Moscow State University, Vorobevy gory, Moscow, 119992, Russian Federation
^eTexas A&M University, College Station, Texas, USA

Methods of optical physics offer unique opportunities for the investigation of brain and higher nervous activity. The integration of cutting-edge laser technologies and advanced neurobiology opens a new cross-disciplinary direction of natural sciences — neurophotonics, leading to the development of a vast arsenal of tools for functional brain diagnostics, stimulation of individual neurons and neural networks, as well as molecular engineering of brain cells aimed at a diagnosis and therapy of neurodegenerative and psychic diseases. Optical fibers suggest unique approaches helping to confront the most challenging problems in brain research, including the analysis of cellular and molecular mechanisms behind memory and cognition. Optical fibers of new generation offer new solutions for the development of fundamentally new, unique tools for neurophotonics and laser neuroengineering — fiber-optic neuroendoscopes and neurointerfaces. These instruments open new horizons for the investigation of the most complex brain functions, enabling a long-term multiplex detection of fluorescent protein markers, as well as photostimulation of neuronal activity in deep brain areas in living, freely behaving animals with an unprecedented spatial resolution and minimal invasiveness. This emerging technology opens new horizons for understanding learning and long-term memory through experiments with living, freely behaving mammals. Here, we offer a brief review of this rapidly growing field of research.

Keywords: neurophotonics, fiber-optic probes, nonlinear-optical microscopy
PACS: 42.81.−i, 87.19.L−, 87.85.D− (all)
DOI: 10.3367/UFNe.0185.201504c.0371
URL: https://ufn.ru/en/articles/2015/4/c/
Web of Science

000357718100003
Scopus

2-s2.0-84936750581
ADS NASA

2015PhyU...58..345D
Citation: Doronina-Amitonova L V, Fedotov I V, Fedotov A B, Anokhin K V, Zheltikov A M "Neurophotonics: optical methods to study and control the brain" Phys. Usp. 58 345–364 (2015)

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Received: 25th, December 2014, accepted: 30th, December 2014

Оригинал: Доронина-Амитонова Л В, Федотов И В, Федотов А Б, Анохин К В, Жёлтиков А М «Нейрофотоника: оптические методы исследования и управления мозгом» УФН 185 371–392 (2015); DOI: 10.3367/UFNr.0185.201504c.0371

References (185) Cited by (40) Similar articles (20) ↓

A.M. Zheltikov “The Raman effect in femto- and attosecond physics” 54 29–51 (2011)
A.M. Zheltikov “Let there be white light: supercontinuum generation by ultrashort laser pulses” 49 605–628 (2006)
A.M. Zheltikov “Nonlinear optics of microstructure fibers” 47 69–98 (2004)
A.A. Ivanov, M.V. Alfimov, A.M. Zheltikov “Femtosecond pulses in nanophotonics” 47 687–704 (2004)
M.I. Rabinovich, M.K. Muezzinoglu “Nonlinear dynamics of the brain: emotion and cognition” 53 357–372 (2010)
A.M. Zheltikov “Holey fibers” 43 1125–1136 (2000)
A.M. Zheltikov, N.I. Koroteev “Coherent four-wave mixing in excited and ionized gas media: four-photon spectrochronography, ellipsometry, and nonlinear-optical imaging of atoms and ions” 42 321–351 (1999)
G.R. Ivanitskii “21st century: what is life from the perspective of physics?” 53 327–356 (2010)
M.B. Menskii “Concept of consciousness in the context of quantum mechanics” 48 389–409 (2005)
V.S. Popov “Tunnel and multiphoton ionization of atoms and ions in a strong laser field (Keldysh theory)” 47 855–885 (2004)
D.S. Chernavskii “The origin of life and thinking from the viewpoint of modern physics” 43 151–176 (2000)
P.G. Kryukov “Continuous-wave femtosecond lasers” 56 849–867 (2013)
G.N. Borisyuk, R.M. Borisyuk et al “Models of neural dynamics in brain information processing — the developments of ’the decade’” 45 1073–1095 (2002)
N.B. Delone “Multiphoton ionization of atoms” 18 169–189 (1975)
O.V. Butov, K.A. Tomyshev et al “Tilted fiber Bragg gratings and their sensing applications” 65 1290–1302 (2022)
G.R. Ivanitskii, A.B. Medvinskii, M.A. Tsyganov “From disorder to order as applied to the movement of micro-organisms” 34 (4) 289–316 (1991)
B.M. Karnakov, V.D. Mur et al “Current progress in developing the nonlinear ionization theory of atoms and ions” 58 3–32 (2015)
A.M. Zheltikov “Isolated waveguide modes of high-intensity light fields” 47 1205–1220 (2004)
V.V. Klinshov, V.I. Nekorkin “Synchronization of delay-coupled oscillator networks” 56 1217–1229 (2013)
M.A. Tsyganov, V.N. Biktashev et al “Waves in systems with cross-diffusion as a new class of nonlinear waves” 50 263–286 (2007)

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