Instruments and methods of investigation

Accelerator-based neutron source for boron neutron capture therapy

 a, b,  c, d,  a, b,  a,  a,  a,  d,  a, b,  a, b,  a, b,  d,  a,  a,  a,  a,  a, d,  a, b,  a, b,  a,  a,  a
a Budker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences, prosp. akad. Lavrenteva 11, Novosibirsk, 630090, Russian Federation
b Novosibirsk State University, ul. Pirogova2, Novosibirsk, 630090, Russian Federation
c TAE Life Sciences, 19631 Pauling, Foothill Ranch, CA, 92610, USA
d TAE Technologies, 19631 Pauling, Foothill Ranch, CA, 92610, USA

An accelerator-based neutron source is being developed for boron neutron capture therapy (BNCT) of oncological diseases. In the source, neutrons are produced through interaction of a proton beam accelerated in an electrostatic tandem accelerator with a lithium target. The source generates an optimal neutron beam for BNCT treatment, and has several unique practical characteristics that make it ideally suited for clinical use. Namely, the tandem accelerator is compact (its design does not utilize accelerator tubes), reliable, simple and flexible in operation, and relatively inexpensive. The paper provides a comprehensive overview of studies of the neutron source prototype and preliminary test results of the first specialized neutron source for clinical trials of BNCT.

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Fulltext is also available at DOI: 10.3367/UFNe.2021.02.038940
Keywords: accelerator-based neutron source, electrostatic accelerator, boron neutron capture therapy, negative hydrogen ion source
PACS: 29.20.−c, 29.25.Dz, 87.19.xj, 87.53.−j, 87.55.−x (all)
DOI: 10.3367/UFNe.2021.02.038940
Citation: Ivanov A A, Smirnov A N, Taskaev S Yu, Bayanov B F, Belchenko Yu I, Davydenko V I, Dunaevsky A, Emelev I S, Kasatov D A, Makarov A N, Meekins M, Kuksanov N K, Popov S S, Salimov R A, Sanin A L, Sorokin I N, Sycheva T V, Shudlo I M, Vorob’ev D S, Cherepkov V G, Fadeev S N "Accelerator-based neutron source for boron neutron capture therapy" Phys. Usp. 65 834–851 (2022)
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Received: 30th, March 2021, revised: 7th, April 2021, 8th, April 2021

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