Accelerator-based neutron source for boron neutron capture therapy

A.A. Ivanov^a, b, A.N. Smirnov^c, d, S.Yu. Taskaev^a, b, B.F. Bayanov^a, Yu.I. Belchenko^a, V.I. Davydenko^a, A. Dunaevsky^d, I.S. Emelev^a, b, D.A. Kasatov^a, b, A.N. Makarov^a, b, M. Meekins^d, N.K. Kuksanov^a, S.S. Popov^a, R.A. Salimov^a, A.L. Sanin^a, I.N. Sorokin^a, d, T.V. Sycheva^a, b, I.M. Shudlo^a, b, D.S. Vorob’ev^a, V.G. Cherepkov^a, S.N. Fadeev^a
^aBudker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences, prosp. akad. Lavrenteva 11, Novosibirsk, 630090, Russian Federation
^bNovosibirsk State University, ul. Pirogova 2, Novosibirsk, 630090, Russian Federation
^cTAE Life Sciences, 19631 Pauling, Foothill Ranch, CA, 92610, USA
^dTAE Technologies, 19631 Pauling, Foothill Ranch, CA, 92610, USA

An accelerator-based neutron source is being developed for boron neutron capture therapy (BNCT) of oncological diseases. In the source, neutrons are produced through interaction of a proton beam accelerated in an electrostatic tandem accelerator with a lithium target. The source generates an optimal neutron beam for BNCT treatment, and has several unique practical characteristics that make it ideally suited for clinical use. Namely, the tandem accelerator is compact (its design does not utilize accelerator tubes), reliable, simple and flexible in operation, and relatively inexpensive. The paper provides a comprehensive overview of studies of the neutron source prototype and preliminary test results of the first special„ized neutron source for clinical trials of BNCT.

Keywords: accelerator-based neutron source, electrostatic accelerator, boron neutron capture therapy, negative hydrogen ion source
PACS: 29.20.−c, 29.25.Dz, 87.19.xj, 87.53.−j, 87.55.−x (all)
DOI: 10.3367/UFNe.2021.02.038940
URL: https://ufn.ru/en/articles/2022/8/d/
Web of Science

001099034300004
Scopus

2-s2.0-85180477016
Citation: Ivanov A A, Smirnov A N, Taskaev S Yu, Bayanov B F, Belchenko Yu I, Davydenko V I, Dunaevsky A, Emelev I S, Kasatov D A, Makarov A N, Meekins M, Kuksanov N K, Popov S S, Salimov R A, Sanin A L, Sorokin I N, Sycheva T V, Shudlo I M, Vorob’ev D S, Cherepkov V G, Fadeev S N "Accelerator-based neutron source for boron neutron capture therapy" Phys. Usp. 65 834–851 (2022)

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PT Journal Article
TI Accelerator-based neutron source for boron neutron capture therapy
AU Ivanov A A
FAU Ivanov AA
AU Smirnov A N
FAU Smirnov AN
AU Taskaev S Yu
FAU Taskaev SY
AU Bayanov B F
FAU Bayanov BF
AU Belchenko Yu I
FAU Belchenko YI
AU Davydenko V I
FAU Davydenko VI
AU Dunaevsky A
FAU Dunaevsky A
AU Emelev I S
FAU Emelev IS
AU Kasatov D A
FAU Kasatov DA
AU Makarov A N
FAU Makarov AN
AU Meekins M
FAU Meekins M
AU Kuksanov N K
FAU Kuksanov NK
AU Popov S S
FAU Popov SS
AU Salimov R A
FAU Salimov RA
AU Sanin A L
FAU Sanin AL
AU Sorokin I N
FAU Sorokin IN
AU Sycheva T V
FAU Sycheva TV
AU Shudlo I M
FAU Shudlo IM
AU Vorob’ev D S
FAU Vorob’ev DS
AU Cherepkov V G
FAU Cherepkov VG
AU Fadeev S N
FAU Fadeev SN
DP 10 Aug, 2022
TA Phys. Usp.
VI 65
IP 8
PG 834-851
RX 10.3367/UFNe.2021.02.038940
URL https://ufn.ru/en/articles/2022/8/d/
SO Phys. Usp. 2022 Aug 10;65(8):834-851

Received: 30th, March 2021, revised: 7th, April 2021, accepted: 8th, April 2021

Оригинал: Иванов А А, Смирнов А Н, Таскаев С Ю, Баянов Б Ф, Бельченко Ю И, Давыденко В И, Дунаевский А, Емелев И С, Касатов Д А, Макаров А Н, Микенс М, Куксанов Н К, Попов С С, Санин А Л, Сорокин И Н, Сычёва Т В, Щудло И М, Воробьев Д С, Черепков В Г, Фадеев С Н «Ускорительный источник нейтронов для бор-нейтронозахватной терапии» УФН 192 893–912 (2022); DOI: 10.3367/UFNr.2021.02.038940