Accelerator-based neutron source for boron neutron capture therapy

A.A. Ivanov^a, b, A.N. Smirnov^c, d, S.Yu. Taskaev^a, b, B.F. Bayanov^a, Yu.I. Belchenko^a, V.I. Davydenko^a, A. Dunaevsky^d, I.S. Emelev^a, b, D.A. Kasatov^a, b, A.N. Makarov^a, b, M. Meekins^d, N.K. Kuksanov^a, S.S. Popov^a, R.A. Salimov^a, A.L. Sanin^a, I.N. Sorokin^a, d, T.V. Sycheva^a, b, I.M. Shudlo^a, b, D.S. Vorob’ev^a, V.G. Cherepkov^a, S.N. Fadeev^a
^aBudker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences, prosp. akad. Lavrenteva 11, Novosibirsk, 630090, Russian Federation
^bNovosibirsk State University, ul. Pirogova 2, Novosibirsk, 630090, Russian Federation
^cTAE Life Sciences, 19631 Pauling, Foothill Ranch, CA, 92610, USA
^dTAE Technologies, 19631 Pauling, Foothill Ranch, CA, 92610, USA

An accelerator-based neutron source is being developed for boron neutron capture therapy (BNCT) of oncological diseases. In the source, neutrons are produced through interaction of a proton beam accelerated in an electrostatic tandem accelerator with a lithium target. The source generates an optimal neutron beam for BNCT treatment, and has several unique practical characteristics that make it ideally suited for clinical use. Namely, the tandem accelerator is compact (its design does not utilize accelerator tubes), reliable, simple and flexible in operation, and relatively inexpensive. The paper provides a comprehensive overview of studies of the neutron source prototype and preliminary test results of the first special„ized neutron source for clinical trials of BNCT.

Keywords: accelerator-based neutron source, electrostatic accelerator, boron neutron capture therapy, negative hydrogen ion source
PACS: 29.20.−c, 29.25.Dz, 87.19.xj, 87.53.−j, 87.55.−x (all)
DOI: 10.3367/UFNe.2021.02.038940
URL: https://ufn.ru/en/articles/2022/8/d/
Web of Science

001099034300004
Scopus

2-s2.0-85180477016
Citation: Ivanov A A, Smirnov A N, Taskaev S Yu, Bayanov B F, Belchenko Yu I, Davydenko V I, Dunaevsky A, Emelev I S, Kasatov D A, Makarov A N, Meekins M, Kuksanov N K, Popov S S, Salimov R A, Sanin A L, Sorokin I N, Sycheva T V, Shudlo I M, Vorob’ev D S, Cherepkov V G, Fadeev S N "Accelerator-based neutron source for boron neutron capture therapy" Phys. Usp. 65 834–851 (2022)

BibTexBibNote ® (generic)BibNote ® (RIS)MedlineRefWorks

Received: 30th, March 2021, revised: 7th, April 2021, accepted: 8th, April 2021

Оригинал: Иванов А А, Смирнов А Н, Таскаев С Ю, Баянов Б Ф, Бельченко Ю И, Давыденко В И, Дунаевский А, Емелев И С, Касатов Д А, Макаров А Н, Микенс М, Куксанов Н К, Попов С С, Санин А Л, Сорокин И Н, Сычёва Т В, Щудло И М, Воробьев Д С, Черепков В Г, Фадеев С Н «Ускорительный источник нейтронов для бор-нейтронозахватной терапии» УФН 192 893–912 (2022); DOI: 10.3367/UFNr.2021.02.038940