Microtubule: a dynamically unstable stochastic phase switching polymer

P.N. Zakharov^a, V.K. Arzhanik^b, E.V. Ulyanov^c, N.B. Gudimchuk^c, d, a, F.I. Ataullakhanov^c, d, a
^aCenter for Theoretical Problems of Physicochemical Pharmacology RAS, ul. Kosygina 4, Moscow, 119991, Russian Federation
^bLomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Leninskie Gory 1, building 73, Moscow, 119234, Russian Federation
^cLomonosov Moscow State University, Faculty of Physics, Leninskie Gory 1 build. 2, Moscow, 119991, Russian Federation
^dFederal Research Center of Pediatric Hematology, Oncology and Immunology, ul. Samory Mashela 1, Moscow, 117997, Russian Federation

One of the simplest molecular motors, a biological microtubule, is reviewed as an example of a highly nonequilibrium molecular machine capable of stochastic transitions between slow growth and rapid disassembly phases. Basic properties of the microtubule are described, and various approaches to simulating its dynamics, from statistical chemical kinetics models to molecular dynamics models using the Metropolis Monte Carlo and Brownian dynamics methods, are outlined.

Keywords: microtubule, GTP-cap, mathematical modeling, dynamic instability
PACS: 87.10.−e, 87.16.−b, 87.16.A− (all)
DOI: 10.3367/UFNe.2016.04.037779
URL: https://ufn.ru/en/articles/2016/8/b/
Web of Science

000388449500002
Scopus

2-s2.0-84995595663
ADS NASA

2016PhyU...59..773Z
Citation: Zakharov P N, Arzhanik V K, Ulyanov E V, Gudimchuk N B, Ataullakhanov F I "Microtubule: a dynamically unstable stochastic phase switching polymer" Phys. Usp. 59 773–786 (2016)

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Received: 14th, March 2016, revised: 4th, April 2016, accepted: 12th, April 2016

Оригинал: Захаров П Н, Аржаник В К, Ульянов Е В, Гудимчук Н Б, Атауллаханов Ф И «Микротрубочка — динамически нестабильный биополимер со спонтанными переключениями между фазовыми состояниями» УФН 186 853–868 (2016); DOI: 10.3367/UFNr.2016.04.037779

References (105) Cited by (10) Similar articles (20) ↓

Yu.M. Romanovsky, A.N. Tikhonov “Molecular energy transducers of the living cell. Proton ATP synthase: a rotating molecular motor” Phys. Usp. 53 893–914 (2010)
Yu.M. Romanovsky, V.P. Trifonenkov “Energetics and stochastic dynamics of intraneuron transport” Phys. Usp. 59 121–140 (2016)
F.I. Ataullakhanov, V.I. Zarnitsyna et al “A new class of stopping self-sustained waves: a factor determining the spatial dynamics of blood coagulation” Phys. Usp. 45 619–636 (2002)
G.R. Ivanitskii “21st century: what is life from the perspective of physics?” Phys. Usp. 53 327–356 (2010)
V.I. Belinicher, B.I. Sturman “The photogalvanic effect in media lacking a center of symmetry” Sov. Phys. Usp. 23 199–223 (1980)
D.N. Zubarev “Double-time Green functions in statistical physics” Sov. Phys. Usp. 3 320–345 (1960)
D.K. Belashchenko “Computer simulation of liquid metals” Phys. Usp. 56 1176–1216 (2013)
O.V. Maslennikov, V.I. Nekorkin “Adaptive dynamical networks” Phys. Usp. 60 694–704 (2017)
V.V. Klinshov, V.I. Nekorkin “Synchronization of delay-coupled oscillator networks” Phys. Usp. 56 1217–1229 (2013)
A.G. Syromyatnikov, S.V. Kolesnikov et al “Formation and properties of metallic atomic chains and wires” Phys. Usp. 64 671–701 (2021)
V.L. Popov, A.E. Filippov, S.N. Gorb “Biological microstructures with high adhesion and friction. Numerical approach” Phys. Usp. 59 829–845 (2016)
L.I. Krishtalik “Proteins as specific polar media for charge transfer processes” Phys. Usp. 55 1192–1213 (2012)
E.F. Sheka “Spectroscopy of amorphous substances with molecular structure” Sov. Phys. Usp. 33 (2) 147–166 (1990)
R.S. Berry, B.M. Smirnov “Modeling of configurational transitions in atomic systems” Phys. Usp. 56 973–998 (2013)
V.P. Tychinskii “Dynamic phase microscopy: is a “dialogue” with the cell possible?” Phys. Usp. 50 513–528 (2007)
Yu.B. Kudasov, A.S. Korshunov et al “Frustrated lattices of Ising chains” Phys. Usp. 55 1169–1191 (2012)
N.M. Chernavskaya, D.S. Chernavskii “Periodic phenomena in photosynthesis” Sov. Phys. Usp. 3 850–865 (1961)
G.N. Sarkisov “Approximate equations of the theory of liquids in the statistical thermodynamics of classical liquid systems” Phys. Usp. 42 545–561 (1999)
V.A. Tverdislov, E.V. Malyshko “On regularities in the spontaneous formation of structural hierarchies in chiral systems of nonliving and living matter” Phys. Usp. 62 354–363 (2019)
M.D. Frank-Kamenetskii, V.V. Anshelevich, A.V. Lukashin “Polyelectrolyte model of DNA” Sov. Phys. Usp. 30 317–330 (1987)

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