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Microtubule: a dynamically unstable stochastic phase switching polymer

 a,  b,  c,  c, d, a,  c, d, a
a Center for Theoretical Problems of Physicochemical Pharmacology RAS, ul. Kosygina 4, Moscow, 119991, Russian Federation
b Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Leninskie Gory 1, building 73, Moscow, 119234, Russian Federation
c Lomonosov Moscow State University, Faculty of Physics, Leninskie Gory 1 build. 2, Moscow, 119991, Russian Federation
d Federal Research Center of Pediatric Hematology, Oncology and Immunology, ul. Samory Mashela 1, Moscow, 117997, Russian Federation

One of the simplest molecular motors, a biological microtubule, is reviewed as an example of a highly nonequilibrium molecular machine capable of stochastic transitions between slow growth and rapid disassembly phases. Basic properties of the microtubule are described, and various approaches to simulating its dynamics, from statistical chemical kinetics models to molecular dynamics models using the Metropolis Monte Carlo and Brownian dynamics methods, are outlined.

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Fulltext is also available at DOI: 10.3367/UFNe.2016.04.037779
Keywords: microtubule, GTP-cap, mathematical modeling, dynamic instability
PACS: 87.10.−e, 87.16.−b, 87.16.A− (all)
DOI: 10.3367/UFNe.2016.04.037779
URL: https://ufn.ru/en/articles/2016/8/b/
000388449500002
2-s2.0-84995595663
2016PhyU...59..773Z
Citation: Zakharov P N, Arzhanik V K, Ulyanov E V, Gudimchuk N B, Ataullakhanov F I "Microtubule: a dynamically unstable stochastic phase switching polymer" Phys. Usp. 59 773–786 (2016)
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Received: 14th, March 2016, revised: 4th, April 2016, 12th, April 2016

Оригинал: Захаров П Н, Аржаник В К, Ульянов Е В, Гудимчук Н Б, Атауллаханов Ф И «Микротрубочка — динамически нестабильный биополимер со спонтанными переключениями между фазовыми состояниями» УФН 186 853–868 (2016); DOI: 10.3367/UFNr.2016.04.037779

References (105) ↓ Cited by (10) Similar articles (20)

  1. Kline-Smith S L, Walczak C E Mol. Cell 15 317 (2004)
  2. Cimini D, Degrassi F Trends Cell Biol. 15 442 (2005)
  3. Bakhoum S F, Compton D A Curr. Opin. Cell Biol. 24 64 (2012)
  4. Nicholson J M, Cimini D Int. Rev. Cell Mol. Biol. 315 299 (2015)
  5. Walczak C E, Heald R Int. Rev. Cytol. 265 111 (2008)
  6. Erickson H P, O’Brien E T Annu. Rev. Biophys. Biomol. Struct. 21 145 (1992)
  7. Bouchet-Marquis C et al. Biol. Cell 99 45 (2007)
  8. Nogales E, Ramey V H, Wang H-W Methods Cell Biol. 95 129 (2010)
  9. Chrétien D et al. Cell Struct. Funct. 24 299 (1999)
  10. Kirschner M W, Mitchison T Nature 324 621 (1986)
  11. Asbury C L et al. Proc. Natl. Acad. Sci. USA 103 9873 (2006)
  12. Molodtsov M I et al. Proc. Natl. Acad. Sci. USA 102 4353 (2005)
  13. Volkov V A et al. Proc. Natl. Acad. Sci. USA 110 7708 (2013)
  14. Hill T L, Chen Y Proc. Natl. Acad. Sci. USA 81 5772 (1984)
  15. Meurer-Grob P, Kasparian J, Wade R H Biochemistry 40 8000 (2001)
  16. Chrétien D, Flyvbjerg H, Fuller S D Eur. Biophys. J. 27 490 (1998)
  17. Hirose K, Fan J, Amos L A J. Mol. Biol. 251 329 (1995)
  18. Horio T, Hotani H Nature 321 605 (1986)
  19. Mitchison T J Science 261 1044 (1993)
  20. Vale R D et al. Philos. Trans. R. Soc. Lond. B B 355 449 (2000)
  21. Desai A, Mitchison T J Annu. Rev. Cell Dev. Biol. 13 83 (1997)
  22. Mandelkow E M et al. J. Cell Biol. 102 1067 (1986)
  23. Wade R H, Chrétien D J. Struct. Biol. 110 1 (1993)
  24. Mandelkow E M, Mandelkow E J. Mol. Biol. 181 123 (1985)
  25. Mandelkow E M EMBO J. 7 357 (1988)
  26. Mandelkow E M, Mandelkow E, Milligan R A J. Cell Biol. 114 977 (1991)
  27. Mitchison T, Kirschner M Nature 312 237 (1984)
  28. Zakharov P et al. Biophys. J. 109 2574 (2015)
  29. David-Pfeuty T, Erickson H P, Pantaloni D Proc. Natl. Acad. Sci. USA 74 5372 (1977)
  30. Weisenberg R C, Deery W J, Dickinson P J Biochemistry 15 4248 (1976)
  31. Spiegelman B M, Penningroth S M, Kirschner M W Cell 12 587 (1977)
  32. Caplow M, Shanks J J. Biol. Chem. 265 8935 (1990)
  33. Tran P T, Walker R A, Salmon E D J. Cell Biol. 138 105 (1997)
  34. Müller-Reichert T et al. Proc. Natl. Acad. Sci. USA 95 3661 (1998)
  35. Wang H-W, Nogales E Nature 435 911 (2005)
  36. Rice L M, Montabana E A, Agard D A Proc. Natl. Acad. Sci. USA 105 5378 (2008)
  37. Brouhard G J Mol. Biol. Cell 26 1207 (2015)
  38. Hyman A A et al. Mol. Biol. Cell 3 1155 (1992)
  39. Walker R A, Inoué S, Salmon E D J. Cell Biol. 108 931 (1989)
  40. O’Brien E T, Voter W A, Erickson H P Biochemistry 26 4148 (1987)
  41. Stewart R J, Farrell K W, Wilson L Biochemistry 29 6489 (1990)
  42. Walker R A, Pryer N K, Salmon E D J. Cell Biol. 114 73 (1991)
  43. Voter W A, O’Brien E T, Erickson H P Cell Motil. Cytoskeleton 18 55 (1991)
  44. Walker R A et al. J. Cell Biol. 107 1437 (1988)
  45. Drechsel D N, Kirschner M W Curr. Biol. 4 1053 (1994)
  46. Caplow M, Shanks J Mol. Biol. Cell 7 663 (1996)
  47. Gardner M K et al. Cell 146 582 (2011)
  48. Maurer S P et al. Cell 149 371 (2012)
  49. Bieling P et al. Nature 450 1100 (2007)
  50. Odde D J, Cassimeris L, Buettner H M Biophys. J. 69 796 (1995)
  51. Gardner M K et al. Cell 147 1092 (2011)
  52. Olkin I, Gleser L J, Derman C Probability Models And Applications (New York: Macmillan, 1980)
  53. Bowne-Anderson H et al. BioEssays 35 452 (2013)
  54. Coombes C E et al. Curr. Biol. 23 1342 (2013)
  55. Maurer S P et al. Curr. Biol. 24 372 (2014)
  56. Chrétien D, Fuller S D, Karsenti E J. Cell Biol. 129 1311 (1995)
  57. Grishchuk E L et al. Nature 438 384 (2005)
  58. Lampert F, Hornung P, Westermann S J. Cell Biol. 189 641 (2010)
  59. Carter N J, Cross R A Nature 435 308 (2005)
  60. Mallik R et al. Nature 427 649 (2004)
  61. Gennerich A et al. Cell 131 952 (2007)
  62. Grishchuk E L, McIntosh J R EMBO J. 25 4888 (2006)
  63. Tanaka K et al. J. Cell Biol. 178 269 (2007)
  64. Chen Y D, Hill T L Proc. Natl. Acad. Sci. USA 82 1131 (1985)
  65. Bayley P, Schilstra M, Martin S FEBS Lett. 259 181 (1989)
  66. Bayley P M, Schilstra M J, Martin S R J. Cell Sci. 95 33 (1990)
  67. Martin S R, Schilstra M J, Bayley P M Biochim. Biophys. Acta 1073 555 (1991)
  68. Flyvbjerg H, Holy T E, Leibler S Phys. Rev. Lett. 73 2372 (1994)
  69. Martin S R, Schilstra M J, Bayley P M Biophys. J. 65 578 (1993)
  70. Efremov A et al. Proc. Natl. Acad. Sci. USA 104 19017 (2007)
  71. Molodtsov M I et al. Biophys. J. 88 3167 (2005)
  72. Sept D, MacKintosh F C Phys. Rev. Lett. 104 018101 (2010)
  73. Sept D, Baker N A, McCammon J A Protein Sci. 12 2257 (2009)
  74. VanBuren V, Odde D J, Cassimeris L Proc. Natl. Acad. Sci. USA 99 6035 (2002)
  75. VanBuren V, Cassimeris L, Odde D J Biophys. J. 89 2911 (2005)
  76. Gregoretti I V et al. J. Cell Sci. 119 4781 (2006)
  77. Brun L et al. Proc. Natl. Acad. Sci. USA 106 21173 (2009)
  78. Ranjith P et al. Biophys. J. 96 2146 (2009)
  79. Piette B M et al. PLoS ONE 4 e6378 (2009)
  80. Margolin G et al. Mol. Biol. Cell 23 642 (2012)
  81. Castle B T, Odde D J Biophys. J. 105 2528 (2013)
  82. Padinhateeri R, Kolomeisky A B, Lacoste D Biophys. J. 102 1274 (2012)
  83. Hinow P, Rezania V, Tuszyński J A Phys. Rev. E 80 031904 (2009)
  84. Mazilu I, Zamora G, Gonzalez J Physica A 389 419 (2010)
  85. Margolin G et al. Phys. Rev. E 74 041920 (2006)
  86. Flyvbjerg H, Holy T E, Leibler S Phys. Rev. E 54 5538 (1996)
  87. Gillespie D T J. Comput. Phys. 22 403 (1976)
  88. Chrétien D, Fuller S D J. Mol. Biol. 298 663 (2000)
  89. Gillespie D T Annu. Rev. Phys. Chem. 58 35 (2007)
  90. Gillespie D T J. Phys. Chem. 81 2340 (1977)
  91. Gillespie D T Physica A 188 404 (1992)
  92. Hill T L, Kirschner M W Int. Rev. Cytol. 78 1 (1982)
  93. Jánosi I M, Chrétien D, Flyvbjerg H Eur. Biophys. J. 27 501 (1998)
  94. Jánosi I M, Chrétien D, Flyvbjerg H Biophys. J. 83 1317 (2002)
  95. Jiang L et al. Proteins 46 190 (2002)
  96. Hyman A A et al. Mol. Biol. Cell 3 1155 (1992)
  97. Metropolis N, Ulam S J. Am. Stat. Assoc. 44 335 (1949)
  98. Metropolis N et al. J. Chem. Phys. 21 1087 (1953)
  99. Rossky P J, Doll J D, Friedman H L J. Chem. Phys. 69 4628 (1978)
  100. Chen J C, Kim A S Adv. Colloid Interface Sci. 112 159 (2004)
  101. Heyes D M, Branka A C Mol. Phys. 94 447 (1998)
  102. Ermak D L, McCammon J A J. Chem. Phys. 69 1352 (1978)
  103. Rotne J, Prager S J. Chem. Phys. 50 4831 (1969)
  104. Laue T, Demeler B Nature Chem. Biol. 7 331 (2011)
  105. Brouhard G J, Rice L M J. Cell Biol. 207 323 (2014)
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