Reviews of topical problems

Energetics and stochastic dynamics of intraneuron transport

 a,  b
a Lomonosov Moscow State University, Department of Physics, Leninskie Gory 1 build. 2, Moscow, 119991, Russian Federation
b National Research Nuclear University ‘MEPhI’, Kashirskoe shosse 31, Moscow, 115409, Russian Federation

Walking molecular motors performing various functions in living cells are reviewed, including kinesin, myosin V and dynein. These motors ensure the transport of neuromediators in neurons and are therefore crucial for the interaction between the hundred billion of brain cells. Functional schemes based on these motors are presented, and corresponding mathematical models are constructed as systems of two coupled FitzHugh—Nagumo equations. However, polynomials describing the moments of force are of high order and nearly N-shaped. Model parameters are determined from motor functional schemes that are based on data from X-ray crystallography, cryogenic electron microscopy, laser tweezer measurements and fast point marker based videomicroscopy. Basic data on neuron energetics are summarized.

Fulltext is available at IOP
Keywords: neuron, molecular motors, kinesin, myosin V, dynein, adenosine triphosphate (ATP), active site
PACS: 87.10.−e, 87.16.Nn, 87.19.L− (all)
DOI: 10.3367/UFNe.0186.201602b.0125
Citation: Romanovsky Yu M, Trifonenkov V P "Energetics and stochastic dynamics of intraneuron transport" Phys. Usp. 59 121–140 (2016)
BibTexBibNote ® (generic)BibNote ® (RIS)MedlineRefWorks

Received: 12th, October 2015, revised: 11th, November 2015, 12th, November 2015

Оригинал: Романовский Ю М, Трифоненков В П «Энергетика и стохастическая динамика внутринейронного транспорта» УФН 186 125–145 (2016); DOI: 10.3367/UFNr.0186.201602b.0125

References (70) Cited by (4) Similar articles (20) ↓

  1. Yu.M. Romanovsky, A.N. Tikhonov “Molecular energy transducers of the living cell. Proton ATP synthase: a rotating molecular motor53 893–914 (2010)
  2. P.N. Zakharov, V.K. Arzhanik et alMicrotubule: a dynamically unstable stochastic phase switching polymer59 773–786 (2016)
  3. L.I. Krishtalik “Proteins as specific polar media for charge transfer processes55 1192–1213 (2012)
  4. Yu.V. Gulyaev, A.S. Bugaev et alNanotransport controlled by means of the ratchet effect63 311–326 (2020)
  5. Yu.M. Romanovskii, V.A. Teplov “The physical bases of cell movement. The mechanisms of self-organisation of amoeboid motility38 521–542 (1995)
  6. M.I. Rabinovich, M.K. Muezzinoglu “Nonlinear dynamics of the brain: emotion and cognition53 357–372 (2010)
  7. V.V. Klinshov, V.I. Nekorkin “Synchronization of delay-coupled oscillator networks56 1217–1229 (2013)
  8. V.L. Popov, A.E. Filippov, S.N. Gorb “Biological microstructures with high adhesion and friction. Numerical approach59 829–845 (2016)
  9. L.V. Doronina-Amitonova, I.V. Fedotov et alNeurophotonics: optical methods to study and control the brain58 345–364 (2015)
  10. O.V. Maslennikov, V.I. Nekorkin “Adaptive dynamical networks60 694–704 (2017)
  11. A.N. Pavlov, A.E. Hramov et alWavelet analysis in neurodynamics55 845–875 (2012)
  12. V.M. Rozenbaum, V.M. Ogenko, A.A. Chuiko “Vibrational and orientational states of surface atomic groups34 (10) 883–902 (1991)
  13. E.F. Sheka “Spectroscopy of amorphous substances with molecular structure33 (2) 147–166 (1990)
  14. V.I. Belinicher, B.I. Sturman “The photogalvanic effect in media lacking a center of symmetry23 199–223 (1980)
  15. D.N. Zubarev “Double-time Green functions in statistical physics3 320–345 (1960)
  16. G.R. Ivanitskii “21st century: what is life from the perspective of physics?53 327–356 (2010)
  17. O.G. Bakunin “Stochastic instability and turbulent transport. Characteristic scales, increments, diffusion coefficients58 252–285 (2015)
  18. T. Konstandin “Quantum transport and electroweak baryogenesis56 747–771 (2013)
  19. Yu.Kh. Vekilov, M.A. Chernikov “Quasicrystals53 537–560 (2010)
  20. E.P. Shabalin “What can be expected from the further study of CP and T symmetry violation and CPT invariance tests44 895–918 (2001)

The list is formed automatically.

© 1918–2020 Uspekhi Fizicheskikh Nauk
Email: Editorial office contacts About the journal Terms and conditions