Energetics and stochastic dynamics of intraneuron transport

Yu.M. Romanovsky^a, V.P. Trifonenkov^b
^aLomonosov Moscow State University, Faculty of Physics, Leninskie Gory 1 build. 2, Moscow, 119991, Russian Federation
^bNational Research Nuclear University ‘MEPhI’, Kashirskoe shosse 31, Moscow, 115409, Russian Federation

Walking molecular motors performing various functions in living cells are reviewed, including kinesin, myosin V and dynein. These motors ensure the transport of neuromediators in neurons and are therefore crucial for the interaction between the hundred billion of brain cells. Functional schemes based on these motors are presented, and corresponding mathematical models are constructed as systems of two coupled FitzHugh—Nagumo equations. However, polynomials describing the moments of force are of high order and nearly N-shaped. Model parameters are determined from motor functional schemes that are based on data from X-ray crystallography, cryogenic electron microscopy, laser tweezer measurements and fast point marker based videomicroscopy. Basic data on neuron energetics are summarized.

Keywords: neuron, molecular motors, kinesin, myosin V, dynein, adenosine triphosphate (ATP), active site
PACS: 87.10.−e, 87.16.Nn, 87.19.L− (all)
DOI: 10.3367/UFNe.0186.201602b.0125
URL: https://ufn.ru/en/articles/2016/2/c/
Web of Science

000377714800003
Scopus

2-s2.0-84973139194
ADS NASA

2016PhyU...59..121R
Citation: Romanovsky Yu M, Trifonenkov V P "Energetics and stochastic dynamics of intraneuron transport" Phys. Usp. 59 121–140 (2016)

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Received: 12th, October 2015, revised: 11th, November 2015, accepted: 12th, November 2015

Оригинал: Романовский Ю М, Трифоненков В П «Энергетика и стохастическая динамика внутринейронного транспорта» УФН 186 125–145 (2016); DOI: 10.3367/UFNr.0186.201602b.0125

References (70) Cited by (6) Similar articles (20) ↓

Yu.M. Romanovsky, A.N. Tikhonov “Molecular energy transducers of the living cell. Proton ATP synthase: a rotating molecular motor” 53 893–914 (2010)
P.N. Zakharov, V.K. Arzhanik et al “Microtubule: a dynamically unstable stochastic phase switching polymer” 59 773–786 (2016)
L.I. Krishtalik “Proteins as specific polar media for charge transfer processes” 55 1192–1213 (2012)
V.I. Belinicher, B.I. Sturman “The photogalvanic effect in media lacking a center of symmetry” 23 199–223 (1980)
D.N. Zubarev “Double-time Green functions in statistical physics” 3 320–345 (1960)
Yu.V. Gulyaev, A.S. Bugaev et al “Nanotransport controlled by means of the ratchet effect” 63 311–326 (2020)
Yu.M. Romanovskii, V.A. Teplov “The physical bases of cell movement. The mechanisms of self-organisation of amoeboid motility” 38 521–542 (1995)
M.I. Rabinovich, M.K. Muezzinoglu “Nonlinear dynamics of the brain: emotion and cognition” 53 357–372 (2010)
V.V. Klinshov, V.I. Nekorkin “Synchronization of delay-coupled oscillator networks” 56 1217–1229 (2013)
V.L. Popov, A.E. Filippov, S.N. Gorb “Biological microstructures with high adhesion and friction. Numerical approach” 59 829–845 (2016)
O.V. Maslennikov, V.I. Nekorkin “Adaptive dynamical networks” 60 694–704 (2017)
L.V. Doronina-Amitonova, I.V. Fedotov et al “Neurophotonics: optical methods to study and control the brain” 58 345–364 (2015)
A.N. Pavlov, A.E. Hramov et al “Wavelet analysis in neurodynamics” 55 845–875 (2012)
O.V. Maslennikov, M.M. Pugavko et al “Nonlinear dynamics and machine learning of recurrent spiking neural networks” 65 1020–1038 (2022)
A.N. Pisarchik, A.E. Hramov “Stochastic processes in the brain's neural network and their impact on perception and decision-making” 66 1224–1247 (2023)
V.M. Rozenbaum, V.M. Ogenko, A.A. Chuiko “Vibrational and orientational states of surface atomic groups” 34 (10) 883–902 (1991)
E.F. Sheka “Spectroscopy of amorphous substances with molecular structure” 33 (2) 147–166 (1990)
G.R. Ivanitskii “21st century: what is life from the perspective of physics?” 53 327–356 (2010)
O.G. Bakunin “Stochastic instability and turbulent transport. Characteristic scales, increments, diffusion coefficients” 58 252–285 (2015)
T. Konstandin “Quantum transport and electroweak baryogenesis” 56 747–771 (2013)

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