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Energetics and stochastic dynamics of intraneuron transport

 a,  b
a Lomonosov Moscow State University, Faculty of Physics, Leninskie Gory 1 build. 2, Moscow, 119991, Russian Federation
b National Research Nuclear University ‘MEPhI’, Kashirskoe shosse 31, Moscow, 115409, Russian Federation

Walking molecular motors performing various functions in living cells are reviewed, including kinesin, myosin V and dynein. These motors ensure the transport of neuromediators in neurons and are therefore crucial for the interaction between the hundred billion of brain cells. Functional schemes based on these motors are presented, and corresponding mathematical models are constructed as systems of two coupled FitzHugh—Nagumo equations. However, polynomials describing the moments of force are of high order and nearly N-shaped. Model parameters are determined from motor functional schemes that are based on data from X-ray crystallography, cryogenic electron microscopy, laser tweezer measurements and fast point marker based videomicroscopy. Basic data on neuron energetics are summarized.

Fulltext pdf (1.4 MB)
Fulltext is also available at DOI: 10.3367/UFNe.0186.201602b.0125
Keywords: neuron, molecular motors, kinesin, myosin V, dynein, adenosine triphosphate (ATP), active site
PACS: 87.10.−e, 87.16.Nn, 87.19.L− (all)
DOI: 10.3367/UFNe.0186.201602b.0125
URL: https://ufn.ru/en/articles/2016/2/c/
000377714800003
2-s2.0-84973139194
2016PhyU...59..121R
Citation: Romanovsky Yu M, Trifonenkov V P "Energetics and stochastic dynamics of intraneuron transport" Phys. Usp. 59 121–140 (2016)
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Received: 12th, October 2015, revised: 11th, November 2015, 12th, November 2015

Оригинал: Романовский Ю М, Трифоненков В П «Энергетика и стохастическая динамика внутринейронного транспорта» УФН 186 125–145 (2016); DOI: 10.3367/UFNr.0186.201602b.0125

References (70) ↓ Cited by (6) Similar articles (20)

  1. Ivanitskii G R V S’’ezd biofizikov Rossii, 4 - 10 oktyabrya 2015 g. Materialy Vol. 1 (Rostov-na-Donu: Izd-vo Yuzhnogo federal’nogo un-ta, 2015) p. 26
  2. Romanovskii Yu M, Tikhonov A N Usp. Fiz. Nauk 180 931 (2010); Romanovsky Yu M, Tikhonov A N Phys. Usp. 53 893 (2010)
  3. Chernavskii D S, Khurgin Yu I, Shnol’ S E Mol. Biol. 1 419 (1967)
  4. Chernavskii D S, Chernavskaya N M Belok-mashina. Biologicheskie i Makromolekulyarnye Konstruktsii (M.: Yanus-K, 1999)
  5. Eide J L, Chakraborty A K, Oster G F Biophys. J. 90 4281 (2006)
  6. Kubasova N A, Tsaturyan A K Usp. Biol. Khim. 51 233 (2011)
  7. Roberts A J et al. Nature Rev. Mol. Cell Biol. 14 713 (2013)
  8. Vale R D et al. Cell 40 449 (1985)
  9. Schnapp B J et al. Cell 40 455 (1985)
  10. Squire L et al. (Eds) Fundamental Neuroscience 3rd ed. (San Diego: Academic Press, 2008)
  11. Latanov A V Obshchaya Neirofiziologiya. Kurs Lektsii (M.: Izd-vo MGU, 2013)
  12. R.D. Vale Lab, http://valelab.ucsf.edu/
  13. S.M. Block Lab, https://blocklab.stanford.edu/
  14. G Oster Lab, http://www.cnr.berkeley.edu/~goster/home.html
  15. Leslie A G W, Walker J E Phil. Trans. R. Soc. Lond. B 355 465 (2000); J. Walker Lab, https://walker.biology.missouri.edu/
  16. Gematologicheskii nauchnyi tsentr MZ RF. Laboratoriya fizicheskoi biokhimii, http://fazly.ru/index.php/ru
  17. Rubin A B Biofizika (M. - Izhevsk: Inst. komp’yut. issled., 2013), V 3-kh t.
  18. Murray J D Mathematical Biology Vol. 1 An Introduction (New York: Springer, 2002); Per. na russk. yaz., Myurrei Dzh Matematicheskaya Biologiya. T. 1 Vvedenie (M. - Izhevsk: Inst. komp’yut. issled., 2009)
  19. Howarth C, Gleeson P, Attwell D J Cereb Blood Flow Metab. 32 1222 (2012)
  20. Sokoloff L et al. J. Neurochem. 28 897 (1977)
  21. Jain K K, Fischer B Oxygen In Physiology And Medicine (Eds K K Jain, B Fischer) (Springfield, IL: Charles C. Thomas, 1989) p. 25
  22. Ebeling W, Schimansky-Geier L, Romanovsky Yu M (Eds) Stochastic Dynamics Of Reacting Biomolecules (River Edge, N.J.: World Scientific, 2002)
  23. Chikishev A Yu, Kroo S V, Netrebko A V, Netrebko N V, Romanovsky Yu Stochastic Dynamics Of Reacting Biomolecules (Eds W Ebeling, L Schimansky-Geier, Yu M Romanovsky) (River Edge, N.J.: World Scientific, 2002) p. 206 - 246
  24. Chikishev A Yu, Grishanin B A, Shuvalova E V Stochastic Dynamics Of Reacting Biomolecules (Eds W Ebeling, L Schimansky-Geier, Yu M Romanovsky) (River Edge, N.J.: World Scientific, 2002) p. 247 - 262
  25. Sussman J et al. Science 253 872 (1991)
  26. Reck-Peterson S L, Vale R D, Gennerich A Handbook Of Dynein (Eds K Hirose, L Amos) (Boca Raton, FL: Pan Stanford Publ., 2012) p. 145 - 171
  27. Trybus K M Cell Mol. Life Sci. 65 1378 (2008)
  28. Schnitzer M J, Visscher K, Block S M Nature Cell Biol. 2 718 (2000)
  29. Asbury C L, Fehr A N, Block S M Science 302 2130 (2003)
  30. Sindelar C V, Downing K H Proc. Natl. Acad. Sci. USA 107 4111 (2010)
  31. Hwang W, Lang M J, Karplus M Structure 16 62 (2008)
  32. Kargovskii V, Romanovskii Yu M, Tikhonov A N Biofizika 54 5 (2009); Kargovsky A V, Romanovsky Yu M, Tikhonov A N Biophysics 54 1 (2009)
  33. Pogrebnaya A, Romanovsky Yu, Tikhonov A Fluct. Noise Lett. 5 L217 (2005)
  34. Romanovsky Yu M, Kargovsky A V, Ebeling W Eur. Phys. J. Spec. Top. 222 2465 (2013)
  35. Xing J, Liao J-C, Oster G Proc. Natl. Acad. Sci. USA 102 16539 (2005)
  36. Romanovskii Yu M, Kargovskii A V, Priezzhev A V, Trifonenkov V P "Vnutrikletochnaya avtovolnovaya gidrodinamika i molekulyarnye motory" Trudy XII Mezhdunarodnoi nauchno-tekhnicheskoi konf. "Opticheskie metody issledovaniya potokov" 25 - 28 iyunya 2013 g. (M.: Pero, 2013) p. 1 - 21
  37. Visscher K, Schnitzer M J, Block S M Nature Lett. 400 184 (1999)
  38. Schnitzer M J, Visscher K, Block S M Nature Cell Biol. 2 718 (2000)
  39. Svoboda K, Block S M Annu. Rev. Biophys. Biomol. Struct. 23 247 (1994)
  40. Craiga E M, Linkea H Proc. Natl. Acad. Sci. USA 106 18261 (2009)
  41. Kikkawa M J. Cell Biol. 202 (1) 15 (2013)
  42. Samara L et al. Cell 126 335 (2006)
  43. Sarlah A, Vilfan A Biophys. J. 107 662 (2014)
  44. Allan V Science 345 271 (2014)
  45. Crossley L et al. Bull. Math. Biol. 74 2032 (2012)
  46. Lavrova A I, Postnikov E B, Romanovskii Yu M Usp. Fiz. Nauk 179 1327 (2009); Lavrova A I, Postnikov E B, Romanovsky Yu M Phys. Usp. 52 1239 (2009)
  47. Ebeling W Eur. Phys. J. Spec. Top. 224 1395 (2015)
  48. Gudimchuk N B Priroda (10) 3 (2015)
  49. Westermann S et al. Mol. Cell 17 277 (2005)
  50. McIntosh J R et al. Cell 135 322 (2008)
  51. Stepanova T et al. J. Neurosci. 23 2655 (2003)
  52. Kuznetsova I A, Kuznetsov A V Comput. Meth. Biomech. Biomed. Eng. 18 1485 (2015)
  53. Karamched B R, Bressloff P K Biophys. J. 108 2408 (2015)
  54. Doodhi H et al. Curr. Biol. 24 322 (2014)
  55. Potapova T V idr. Biol. Membrany 28 (3) 45 (2011)
  56. Brazhe A R et al. Interface Focus 1 86 (2010)
  57. Rai A K et al. Cell 152 172 (2013)
  58. Furuta K et al. Proc. Natl. Acad. Sci. USA 110 501 (2013)
  59. Novikov K A Romanyukha A A Trudy XII Vseros. soveshch. po problemam upravleniya. VSPU-2014, Moskva 16 - 19 iyunya 2014 g. (M.: IPU RAN) p. 6595
  60. Romanovskii Yu M, Teplov V A Usp. Fiz. Nauk 165 555 (1995); Romanovskii Yu M, Teplov V A Phys. Usp. 38 521 (1995)
  61. Dembo M Biophys. J. 55 1053 (1989)
  62. Hänggi P, Marchesoni F Rev. Mod. Phys. 81 387 (2009)
  63. Romanczuk P et al. Eur. Phys. J. Spec. Top. 202 1 (2012)
  64. Romanczuk P et al. Chaos 21 047517 (2011)
  65. Hennig D et al. Phys. Rep. 586 1 (2015)
  66. Trifonenkov V P, Kargovskii A V Komp’yuternye Issledovaniya Modelirovanie 6 747 (2014)
  67. Kargovsky A V, Romanovsky Y M, Trifonenkov V P Materials of Intern. Symp. "Biological Motility: New Facts and Hypotheses" (Pushchino: ITEB RAS, 2014) p. 106 - 108
  68. Kargovskii A V, Romanovskii Yu M, Trifonenkov V P, Trifonenkov A V Lektsii Po Neiroinformatike (M.: NIYaU MIFI, 2015) p. 156
  69. Metelina A L Usp. Biol. Khim. 41 29 (2001)
  70. Roberts A J et al. Nature Rev. Mol. Cell Biol. 14 713 (2013)
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