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Dynamical properties and energy landscape of simple globular proteins

,
Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119991, Russian Federation

Analysis of dynamic properties of a simple globular protein, myoglobin, has demonstrated that it possesses a hierarchically organized energy landscape. It shows two types of specific protein motions, besides vibrations: 1) individual motions of small atomic groups — transitions between conformational substates (CS) of the lower tier 2, and 2) cooperative motions of secondary structure elements ( α-helices) — transitions between CS of the upper tier 1. The profile of macromolecule dynamic properties is highly heterogeneous. Only vibrations occur near the active center. The number of CS grows towards the periphery where specific type 1 and 2 motions become predominant. Such a picture is consistent with the concept of a protein as ’a random copolymer slightly edited in the vicinity of the active center’.

Fulltext is available at IOP
PACS: 87.10.+e, 87.15.By, 87.15.He, 87.80.−y (all)
DOI: 10.1070/PU2002v045n11ABEH001145
URL: https://ufn.ru/en/articles/2002/11/b/
Citation: Krupyanskii Yu F, Gol’danskii V I "Dynamical properties and energy landscape of simple globular proteins" Phys. Usp. 45 1131–1151 (2002)
BibTexBibNote ® (generic) BibNote ® (RIS)MedlineRefWorks
TY JOUR
TI Dynamical properties and energy landscape of simple globular proteins
AU Krupyanskii, Yu. F.
AU Gol’danskii, V. I.
PB Physics-Uspekhi
PY 2002
JO Physics-Uspekhi
JF Physics-Uspekhi
JA Phys. Usp.
VL 45
IS 11
SP 1131-1151
UR https://ufn.ru/en/articles/2002/11/b/
ER https://doi.org/10.1070/PU2002v045n11ABEH001145

Оригинал: Крупянский Ю Ф, Гольданский В И «Динамические свойства и энергетичесий ландшафт простых глобулярных белков» УФН 172 1247–1269 (2002); DOI: 10.3367/UFNr.0172.200211b.1247

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