The widespread use of boron isotopes (¹⁰B and ¹¹B) in practice in a number of important industries and in medicine makes the problem of their production urgent and important and causes great interest in the development of effective methods for their separation (enrichment). Recently, research aimed at developing methods for laser isotope separation (LIS) of boron has intensified. A review of the results of research on LIS of boron is presented. The basic principles of laser isotope separation and the necessary conditions for the implementation of laser methods are briefly discussed. The infrared (IR) absorption spectra of boron-containing molecules, with which the experiments on LIS of boron were carried out, are presented and discussed. These spectra form the basis of methods for laser separation of boron isotopes. High-energy and low- energy methods of molecular laser separation of boron isotopes, as well as the physicochemical processes underlying them, are considered. The results of early studies of isotope-selective IR laser dissociation of boron trichloride (BCl₃) molecules using different excitation schemes and 2-chloroethenyldichloroborane (HClC=CHBCl₂), which are of greatest interest for laser separation of boron isotopes, as well as the results of new research are presented and analyzed. The results of studies of selective IR multiphoton dissociation (MPD) of ¹¹BCl₃ molecules in a natural mixture with ¹⁰BCl₃ molecules upon their irradiation with a sensitizer - SF₆ molecules, which are also radical acceptors - Cl atoms formed during the dissociation of BCl₃ molecules - are presented and discussed. It has been shown that the use of a sensitizer leads to a significant increase in the efficiency of dissociation of ¹¹BCl₃ molecules. A systematization of the results on LIS of boron was carried out. Based on an analysis of the research results, the most optimal schemes for the technological implementation of LIS of boron in practice were proposed. A brief historical excursion into research on laser separation of boron isotopes is given.