RSS feeds
ÐóññêèéEnglish
Issue 4, 2024
Volume year page
Issues Authors PACS Subscription For authors

Issues

 / 

2016

 / 

August

←  →

On the 70th anniversary of the Alikhanov Institute of Theoretical and Experimental Physics


Hadron therapy: history, status, prospects

,
Russian Federation State Scientific Center ‘A.I. Alikhanov Institute of Theoretical and Experimental Physics’, ul. Bolshaya Cheremushkinskaya 25, Moscow, 117259, Russian Federation

A brief historical review is given of remote radiation therapy (RT), one of the main cancer treatment methods along with surgery and chemotherapy. Cellular mechanisms of radiation damage are described. Special attention is paid to hadron (proton and ion) therapy, its history, results, problems, challenges, current trends, and prospects. Undeniably great contributions to proton therapy were made by Russian researchers, notably at the experimental centers that operated since the mid last century at the Joint Institute for Nuclear Research, A.I. Alikhanov Institute for Theoretical and Experimental Physics (ITEP) and B.P. Konstantinov Petersburg Institute of Nuclear Physics. In the world's largest ITEP-hosted multiroom proton therapy center, a quarter of global clinical experience was accumulated by 1990.

Fulltext pdf (1.6 MB)
Fulltext is also available at DOI: 10.3367/UFNe.2016.06.037823
Keywords: proton therapy, proton therapy facility, medical electron accelerator, proton cyclotron, proton synchrotron, proton synchrocyclotron, superconductivity, ion therapy, gantry, Bragg curve, radiation exposure, relative biological effectiveness, linear energy transfer
PACS: 87.19.xj, 87.55.−x, 87.56.−v (all)
DOI: 10.3367/UFNe.2016.06.037823
URL: https://ufn.ru/en/articles/2016/8/e/
000388449500005
2-s2.0-84995553855
2016PhyU...59..807K
Citation: Klenov G I, Khoroshkov V S "Hadron therapy: history, status, prospects" Phys. Usp. 59 807–825 (2016)
BibTexBibNote ® (generic)BibNote ® (RIS)MedlineRefWorks

Received: 1st, March 2016, revised: 7th, June 2016, 9th, June 2016

Îðèãèíàë: Êë¸íîâ Ã È, Õîðîøêîâ Â Ñ «Àäðîííàÿ ëó÷åâàÿ òåðàïèÿ: èñòîðèÿ, ñòàòóñ, ïåðñïåêòèâû» ÓÔÍ 186 891–911 (2016); DOI: 10.3367/UFNr.2016.06.037823

References (62) ↓ Cited by (11) Similar articles (6)

  1. Kaprin A D, Starinskii V V, Petrov G V (Red.) Sostoyanie Onkologicheskoi Pomoshchi Naseleniyu Rossii v 2012 G. (M.: MNIOI im. P.A. Gertsena, 2013)
  2. Kaprin A D, Starinskii V V, Petrov G V (Red.) Zlokachestvennye Novoobrazovaniya v Rossii v 2012 G. (M.: MNIOI im. P.A. Gertsena, 2014)
  3. "Cancer treatment with light ions beam in Europe" EULIMA, Final Report, Part 1. General Feasibility Study (Brussels: Commission of the European Communities, 1992)
  4. World Health Organization, http://www.who.int/cancer/en/
  5. Davydova M I, Aksel’ E M (Red.) Statistika Zlokachestvennykh Novoobrazovanii v Rossii i Stranakh SNG v 2012 G. (M.: RONTs, 2014)
  6. American Cancer Society, Cancer Facts and Figures 2013, 2014, http://www.cancer.org/research/cancerfactsstatistics/allcancerfactsfigures/index
  7. Goss P E at al. Lancet Oncol. 15 489 (2014)
  8. Khoroshkov B S Trudy KhKhI Mezhdunarodnoi konf. i diskussionnogo nauchnogo kluba "Novye informatsionnye tekhnologii v meditsine, biologii, farmakologii i ekologii", Ukraina, Krym, Yalta - Gurzuf, 2013 p. 41
  9. Yarmonenko S P Zhizn’, Rak i Radiatsiya (M.: IzdAT, 1993)
  10. Vogel H H (Jr.), Jordan D L Biological Effects Of Neutron And Proton Irradiation. Proc. Of A Symp., Upton, New York, 7 - 11 October 1963 Vol. 2 (Vienna: IAEA, 1964) p. 275
  11. Fowler J F Biological Effects Of Neutron And Proton Irradiation. Proc. Of A Symp., Upton, New York, 7 - 11 October 1963 Vol. 2 (Vienna: IAEA, 1964) p. 185; Fowler J F https://www.iaea.org/inis/collection/NCLCollectionStore/_Public/44/096/44096452.pdf
  12. Kraft G Advances in Hadrontherapy. Proc. of the Intern. Week on Hadrontherapy, European Scientific Institute, Archamps, France, 20 - 24 November 1995 and of the Second Intern. Symp. on Hadrontherapy, PSI, and CERN, Switzerland, 9 -- 13 September 1996 (Intern. Congress Series) Vol. 1144 (Eds U Amaldi, B Larsson, Y Lemoigne) (Amsterdam: Elsevier, 1997) p. 385
  13. Lawrence J H, Aebersold P C, Lawrence E O Proc. Natl. Acad. Sci. USA 22 543 (1936)
  14. Stone R S, Larkin J C (Jr.) Radiology 39 608 (1942)
  15. Stone R S Am. J. Roentgenol. 59 771 (1948)
  16. RT Answers. About Radiation Therapy, http://www.rtanswers.org/statistics/aboutradiationtherapy/
  17. Lindenbraten L D, Korolyuk I P Meditsinskaya Radiologiya i Rentgenologiya (M.: Meditsina, 1993)
  18. Suit H Int. J. Radiat. Oncol. Biol. Phys. 53 798 (2002)
  19. Caterall M et al. Br. Med. J. 2 653 (1974)
  20. Hatanaka H Basic Life Sci. 54 15 (1990)
  21. Vazhenin A V i dr. Materialy Kh Rossiiskogo onkologicheskogo kongressa, 21 - 23 noyabrya 2006 g. (M.: Izd. gruppa RONTs im. N.N. Blokhina RAMN. Klever print, 2006); Vazhenin A V i dr. http://www.rosoncoweb.ru/library/congress/ru/10/
  22. Noda K 2nd Workshop on Hadron Therapy of Cancer, Erice, 23rd May, 2011; Noda K http://erice2011.na.infn.it/TalkContributions/Noda-24.pdf
  23. 52.org, http://www.ptcog.52.org/
  24. Annual Report NIRS (National Institute of Radiological Sciences), 2007, http://www.nirs.go.jp/ENG/publication/annual/index.shtml
  25. Wilson R R Radiology 47 487 (1946)
  26. Sisterson J (Ed.) Particles Newsletter PTCOG (6) (1990)
  27. Gol’din L L, Dzhelepov V P, Lomanov M F, Savchenko O V, Khoroshkov V S "Primenenie tyazhelykh zaryazhennykh chastits vysokoi energii v meditsine" Usp. Fiz. Nauk 110 77 (1973); Gol’din L L, Dzhelepov V P, Lomanov M F, Savchenko O V, Khoroshkov V S Sov. Phys. Usp. 16 402 (1973)
  28. Khoroshkov V S, Minakova E I Eur. J. Phys. 19 523 (1998)
  29. Sisterson J M Abstracts of the XX PTCOG Meeting, Chester, England, May 16 - 18, 1994 (Boston, MA: Proton Therapy Co-Operative Group, 1994) p. 19; Sisterson J M http://www.ptcog.ch/archive/steering_committee_docs/ptcog20-1994/1994_PTCOG_20_Abstracts.pdf
  30. Sisterson J M Proc. of the NIRS Intern. Seminar on the Heavy Charged Particle Therapy for Cancer, Chiba, Japan, November 17 - 19, 1997 Vol. 2 (Chiba, Japan: National Institute for Radiological Sciences, 1997)
  31. Loeffler J S, Smith A R, Suit H D Semin. Oncol. 24 686 (1997)
  32. Slater J D https://three.jsc.nasa.gov/articles/LLUclinical.pdf
  33. The Particle Therapy Co-Operative Group, PTCOG, http://www.ptcog.ch/
  34. Fortov V E, Khoffmann D, Sharkov B Yu Usp. Fiz. Nauk 178 113 (2008); Fortov V E, Hoffmann D H H, Sharkov B Yu Phys. Usp. 51 109 (2008)
  35. Klenov G I, Khoroshkov V S, Chernykh A N Meditsinskaya Fizika (1) 5 (2014)
  36. Khoroshkov V S Yad. Fiz. 69 1760 (2006); Khoroshkov V S Phys. Atom. Nucl. 69 1724 (2006)
  37. The Corporate Strategic Intelligence. MarketR, http://www.csintell.com/marketr.html
  38. ZAO "PROTOM", http://www.protom.ru/
  39. Nauka i tekhnologii Rossii. STRF.ru, http://www.strf.ru/
  40. Tsentr meditsinskoi radiologii i Akademgorodok v Dimitrovgrade, http://dimra.ru/
  41. Stolpner A Meditsina Tselevye Proekty (15) 28 (2013)
  42. Karpunin O V, Klenov G I, Khoroshkov V S III Troitskaya konf. "Meditsinskaya fizika i innovatsii v meditsine", TKMF-3, 3 - 6 iyunya 2008 g., g. Troitsk. Sbornik trudov (Troitsk: Trovant, 2008) p. 320
  43. Klenov G I, Khoroshkov V S III Evraziiskii kongress po meditsinskoi fizike i inzhenerii "Meditsinskaya fizika — 2010", Moskva, MGU im. M.V. Lomonosova, 21 - 25 iyunya 2010 g. Sbornik materialov Vol. 2 (M.: Izd-vo MGU, 2010); Klenov G I, Khoroshkov V S Meditsinskaya Fizika (1) 86 (2015)
  44. Report of the Advisory Group Meeting on the Utilization of Particle Accelerators for Proton Therapy, 7 - 10 July 1998, Vienna, IAEA-F1-AG-1010 (Vienna: IAEA, 1998)
  45. MEVION medical systems, http://www.mevion.com/
  46. VARIAN medical systems, https://www.varian.com/oncology/products/treatment-delivery/probeam-compact-proton-therapy-system
  47. IBA Proton Therapy, http://www.iba-protontherapy.com/
  48. Caporaso G J, Chen Y-J, Sampayan S E "The Dielectric Wall Accelerator" LLNL-JRNL-416544, September 3 (Livermore, CA: Lawrence Livermore National Laboratory, 2009); Caporaso G J, Chen Y-J, Sampayan S E https://e-reports-ext.llnl.gov/pdf/377059.pdf
  49. Amaldi U et al. arXiv:0902.3533
  50. Amaldi U Cyclotrons and Their Applications 2007, 18th Intern. Conf., 1-5 October 2007, Giardini Naxos, Italy (Catania: INFN, 2007) p. 166
  51. Bulanov S V, Khoroshkov V S Particles Newsletter PTCOG (29) 10 (2002)
  52. Bulanov S V, Khoroshkov V S Fizika Plazmy 28 493 (2002); Bulanov S V, Khoroshkov V S Plasma Phys. Rep. 28 453 (2002)
  53. Bulanov S V i dr. Usp. Fiz. Nauk 184 1265 (2014); Bulanov S V et al. Phys. Usp. 57 1149 (2014)
  54. Baur G et al. Phys. Lett. B 368 251 (1996)
  55. Bassler N et al. Radiotherapy Oncology 86 14 (2008)
  56. Gray L, Kalogeropoulos T E Radiat. Res. 97 246 (1984)
  57. Kravchuk L V Usp. Fiz. Nauk 180 665 (2010); Kravchuk L V Phys. Usp. 53 635 (2010)
  58. Akulinichev S V Usp. Fiz. Nauk 184 1363 (2014); Akulinichev S V Phys. Usp. 57 1239 (2014)
  59. Krasavin E A Usp. Fiz. Nauk 186 435 (2016); Krasavin E A Phys. Usp. 59 411 (2016)
  60. Klenov G I, Chernykh A N Meditsinskaya Fizika (2) 18 (2016)
  61. Kurashvili Yu B, Kaprin A D Meditsinskaya Fizika (2) 43 (2016)
  62. Belyaikin E V Meditsinskaya Fizika (2) 74 (2016)
© 1918–2024 Uspekhi Fizicheskikh Nauk
Email: ufn@ufn.ru Editorial office contacts About the journal Terms and conditions