Proteins as specific polar media for charge transfer processes

L.I. Krishtalik
Institute of Physical Chemistry and Electro Chemistry, Russian Academy of Sciences, Leninskii prosp. 31, Moscow, 119991, Russian Federation

A great many of biological processes involve the transfer of charged particles: electrons and protons. The electrostatic interaction of a moving charge with its surroundings, primarily with protein, is the major factor determining the thermodynamics and kinetics involved. This paper treats protein as a pre-organized highly-polar low-dielectric medium that possesses a pre-existent intraprotein electric field, a low reorganization energy, and a wide range of dielectric relaxation times. These specific protein features are the factors controlling the catalytic acceleration of biochemical reactions. Methods for quantitatively calculating the energetics of a number of typical processes are considered, and examples of their application are given.

PACS: 87.10.−e, 87.14.E−, 87.15.−v (all)
DOI: 10.3367/UFNe.0182.201212b.1275
URL: https://ufn.ru/en/articles/2012/12/b/
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000315989900002
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2012PhyU...55.1192K
Citation: Krishtalik L I "Proteins as specific polar media for charge transfer processes" Phys. Usp. 55 1192–1213 (2012)

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@article{Krishtalik:2012,
	author = {L. I. Krishtalik},
	title = {Proteins as specific polar media for charge transfer processes},
	publisher = {Physics-Uspekhi},
	year = {2012},
	journal = {Phys. Usp.},
	volume = {55},
	number = {12},
	pages = {1192-1213},
	url = {https://ufn.ru/en/articles/2012/12/b/},
	doi = {10.3367/UFNe.0182.201212b.1275}
}

Received: 13th, December 2011, revised: 1st, February 2012, accepted: 7th, February 2012

Оригинал: Кришталик Л И «Белки как специфическая полярная среда процессов переноса заряда» УФН 182 1275–1300 (2012); DOI: 10.3367/UFNr.0182.201212b.1275