The free energy released upon the enzymatic hydrolysis of adenosine triphosphate (ATP) is the main source of energy for the functioning of the living cell and all multicellular organisms. The overwhelming majority of ATP molecules are formed by proton ATP synthases, which are the smallest macromolecular electric motors in Nature. This paper reviews the modern concepts of the molecular structure and functioning of the proton ATP synthase, and real-time biophysical experiments on the rotation of the ’rotor’ of this macromolecular motor. Some mathematical models describing the operation of this nanosized macromolecular machine are described.

PACS: 87.10.−e, 87.15.−v, 87.16.−b (all) DOI: 10.3367/UFNe.0180.201009b.0931 URL: https://ufn.ru/en/articles/2010/9/b/ 000286041500002 2-s2.0-78751506517 2010PhyU...53..893R Citation: Romanovsky Yu M, Tikhonov A N "Molecular energy transducers of the living cell. Proton ATP synthase: a rotating molecular motor" Phys. Usp. 53 893–914 (2010) BibTexBibNote ® (generic)BibNote ® (RIS) MedlineRefWorks PT Journal Article TI Molecular energy transducers of the living cell. Proton ATP synthase: a rotating molecular motor AU Romanovsky Yu M FAU Romanovsky YM AU Tikhonov A N FAU Tikhonov AN DP 10 Sep, 2010 TA Phys. Usp. VI 53 IP 9 PG 893-914 RX 10.3367/UFNe.0180.201009b.0931 URL https://ufn.ru/en/articles/2010/9/b/ SO Phys. Usp. 2010 Sep 10;53(9):893-914 Оригинал: Романовский Ю М, Тихонов А Н «Молекулярные преобразователи энергии живой клетки. Протонная АТФ-синтаза — вращающийся молекулярный мотор» УФН 180 931–956 (2010); DOI: 10.3367/UFNr.0180.201009b.0931