Reviews of topical problems

Dynamic phase microscopy: is a “dialogue” with the cell possible?

Moscow State Institute of Radio Engineering, Electronics, and Automatics (Technical University), prosp. Vernadskogo 78, Moscow, 117454, Russian Federation

The metabolic component оf refractivity is considered as an example of а quantifying parameter for the ’vitality’ of cells and organelles. It is shown that intracellular processes can be studied by the dynamic phase microscopy method, which provides real-time information in the form of local changes in the optical path difference. Preliminary results demonstrate the possibility of localizing а ’signal’ and obtaining information under the signal-structure-function scheme and show prospects for conducting а ’dialogue’ with а cell by real-time registering the way in which it responds to changes in external conditions. The mechanism underlying the dependence of refractivity on metabolic states is ехрlained by the contribution of bound water molecules.

Fulltext is available at IOP
PACS: 07.60.−j, 87.16.−b, 87.64.−t (all)
DOI: 10.1070/PU2007v050n05ABEH006222
Citation: Tychinskii V P "Dynamic phase microscopy: is a "dialogue" with the cell possible?" Phys. Usp. 50 513–528 (2007)
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Оригинал: Тычинский В П «Динамическая фазовая микроскопия: возможен ли „диалог“ с клеткой?» УФН 177 535–552 (2007); DOI: 10.3367/UFNr.0177.200705c.0535

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