RSS feeds
РусскийEnglish
Issue 4, 2024
Volume year page
Issues Authors PACS Subscription For authors

Issues

 / 

1999

 / 

August

←  →

Reviews of topical problems


Quantum processes in biological molecules. Enzyme catalysis


Institute of Applied Physics, Academy of Sciences of Moldavia, Grosula str. 5, Kishinev, 277028, Moldavia

The oxidation-reduction enzymatic reaction is treated as a nonadiabatic multiquantum transition from the initial substrate-enzyme complex to a free product and free enzyme, taking into account the contribution of low-frequency (conformational) degrees of freedom of the enzyme molecule to the quantum transition described in terms of the reaction coordinate. It is demonstrated that the electromagnetic field has a marked effect on the enzymatic reaction rate by exciting low-frequency vibrations of enzyme molecules, a fact from which the nature of the so-called narrow biological resonances may be understood. A new mechanism giving rise to ultraviolet radiation from biological membranes is discussed. The theory can be used to explain the origin of ultraviolet radiation and dipole ordering of globular cell proteins.

Fulltext pdf (380 KB)
Fulltext is also available at DOI: 10.1070/PU1999v042n08ABEH000480
PACS: 33.80.Rv, 87.10.+e, 87.15.−v, 82.50.−m (all)
DOI: 10.1070/PU1999v042n08ABEH000480
URL: https://ufn.ru/en/articles/1999/8/c/
000083411000003
Citation: Kovarskii V A "Quantum processes in biological molecules. Enzyme catalysis" Phys. Usp. 42 797–815 (1999)
BibTexBibNote ® (generic)BibNote ® (RIS)MedlineRefWorks

Оригинал: Коварский В А «Квантовые процессы в биологических молекулах. Ферментативный катализ» УФН 169 889–908 (1999); DOI: 10.3367/UFNr.0169.199908c.0889

References (89) ↓ Cited by (25) Similar articles (20)

  1. to the Introduction
  2. I1. Bohr N Quantum Physics and Biology: Atomic Physics and Human Knowledge (New York: John Wiley, 1958)]
  3. I2. Schrödinger E What is Life? The Physical Aspect of the Living Cell (Cambridge: The University Press, 1944) [Translated into Russian (Moscow: Atomizdat, 1972)]
  4. I3. Pullman B, Pullman A Quantum Biochemistry (New York: Interscience Publ., a Division of John Wiley and Sons, 1963) [Translated into Russian (Moscow: Mir, 1965)]
  5. I4. Ladik L Quanten Biochemie fur Chemiker und Biologen (Budapest: Akademiki Kiadoo, 1972)
  6. I5. Vol’kenshteîn M V, Golovanov I B, Sobolev V M Molekulyarnye Orbitali v Énzimologii (Molecular Orbitals in Enzymology, Moscow: Nauka, 1982)
  7. I6. Kovarskiî V A, Perel’man N F, Averbukh I Sh Mnogokvantovye Protsessy (Multiquantum Processes, Moscow: Energoatomizdat, 1985)
  8. I7. Eyring H, Lin S H, Lin S M Basic Chemical Kinetics (New York: Wiley, 1980) [Translated into Russian (Moscow: Mir, 1983)]
  9. I8. Blumenfeld L A Biophys. 11 251 (1978)
  10. I9. Romanovskiî Yu M, Stepanova N V, Chernavskiî D S Matematicheskaya Biofizika (Mathematics in Biophysics, Moscow: Nauka, 1984)
  11. I10. Warshel A, Russel S T Q. Rev. Biophys. 17 283 (1984)
  12. I11. Vol’kenshteîn M V Molekulyarnaya Biofizika (Molecular Biophysics, Moscow: Nauka, 1975)
  13. I12. Pekar S I Issledovaniya po Élektronnoî Teorii Kristallov (Research in Electron Theory of Crystals, Moscow-Leningrad: Gostekhizdat, 1951) [Translated into English (Washington, DC: AEC, 1963)]
  14. I13. Davydov A S Solitony v Molekulyarnykh Sistemakh (Solitons in Molecular Systems, Kiev: Naukova Dumka, 1984) [Translated into English (Dordrecht: Kluwer Acad. Publ., 1991)]
  15. to Sections 2-11
  16. Kovarskiî V A, Perel’man N F, Averbukh I Sh Mnogokvantovye Protsessy (Multiquantum Processes, Moscow: Energoatomizdat, 1985)
  17. Eyring H, Lin S H, Lin S M Basic Chemical Kinetics (New York: Wiley, 1980) [Translated into Russian (Moscow: Mir, 1983)]
  18. Medvedev É S, Osherov V I Teoriya Bezizluchatel’nykh Perekhodov v Mnogoatomnykh Molekulakh (The Theory of Radiationless Transitions in Polyatomic Molecules, Moscow: Nauka, 1983)
  19. Gol’danskiî V I, Trakhtenberg L I, Flerov V N Tunnel’nye Yavleniya v Khimicheskoî Fizike (Tunnelling in Chemical Physics, Moscow: Nauka, 1986)
  20. Belousov A V et al. Biofizika 38 619 (1993)
  21. Averbukh I Sh, Blumenfeld L A, Kovarsky V A, Perelman N F Biochem. Biophys. Acta 873 290 (1986)
  22. Warshel A, Russell S T Q. Rev. Biophys. 17 283 (1984)
  23. Belousov A V, Kovarskiî V A Zh. Eksp. Teor. Fiz 114 1944 (1998) [JETP 87 1053 (1998)]
  24. De Vault D, Parkes J H, Chance B Nature (London) 215 642 (1967)
  25. Jortner J J. Chem. Phys. 64 4860 (1976)
  26. Grigorov L N, Chernavskiî D S Biofizika 17 195 (1972)
  27. Petrov É G Fizika Perenosa Zaryada v Biosistemakh (Physics of Charge Transfer in Biological Systems, Kiev: Naukova dumka, 1984)
  28. Averbukh I Sh et al. Teor. Mat. Fiz. 81 (2) 271 (1989) [Theor. Math. Phys. 81 1200 (1989)]
  29. Kovarskiî V A Izv. Akad. Nauk Resp. Moldova. Ser. Fiz. Tekh. (3) 58 (1994)
  30. Kovarskiî V A Zh. Eksp. Teor. Fiz. 110 1216 (1996) [JETP 83 670 (1996)]
  31. Presman A S Élektromagnitnye Polya i Zhivaya Priroda (Electromagnetic Fields and Living Nature, Moscow: Nauka, 1968)
  32. Mills R E Phys. Rev. A 28 379 (1983)
  33. Lifshits M L Biofizika 17 694 (1972)
  34. Lifshits M L Biofizika 22 744 (1977)
  35. Wu T, Austin S Phys. Lett. A 64 151 (1977)
  36. Webb S J Phys. Rep. 60 201 (1980)
  37. Bykov V P Usp. Fiz. Nauk 161 125 (1991) [Sov. Phys. Usp. 34 910 (1991)]
  38. Vinogradov A V, Janszky J Zh. Eksp. Teor. Fiz. 100 386 (1991) [Sov. Phys. JETP 73 211 (1991)]
  39. Bersuker I B The Jahn-Teller Effect and Vibronic Interactions in Modern Chemistry (New York: Plenum Press, 1984) [Russian edition (Moscow: Nauka, 1987)]
  40. Kovarsky V A Int. J. Quant. Chem. 66 255 (1998)
  41. Stavrov S S, Dikusar I P, Bersuker I B Mol. Biol. 21 338 (1987)
  42. Hamilton G A J. Amer. Chem. Soc. 86 3391 (1964)
  43. Hamilton G A Adv. Enzymol. 32 55 (1969)
  44. Metelitsa D I Aktivatsiya Kisloroda Fermentnymi Sistemami (Oxygen Activation by Enzymatic Systems, Moscow: Nauka, 1982)
  45. Kovarsky V A, Philipp B S, Kovarsky E V Phys. Lett. A 226 321 (1997)
  46. L’Huillier A et al., in Proc. 5th Int. Conf. on Multiphoton Processes (Paris, France, 1990) p. 45
  47. Kovarskiî V A, Perel’man N F Izv. Akad. Nauk Mold. SSR. Ser. Fiz. Tekh. (1) 37 (1973)
  48. Kovarsky V A, Sedletsky O A, in Proc. 7th Int. Conf. on Multiphoton Processes (Garmisch-Partenkirchen, Germany, 1996)
  49. Setlow R B, Pollard E C Molecular Biophysics (Oxford: Pergamon Press, 1962)
  50. Kovarsky V A, Perlin E Yu Phys. Status Solidi 36 793 (1969)
  51. Kovarsky V A Optoelectronic (Bucharest, 1999, in press)
  52. Kovarskiî V A Pis’ma Zh. Tekh. Fiz. 20 (23-24) 59 (1994)
  53. Cooper M S Phys. Lett. A 65 71 (1978)
  54. Radzig A A, Smirnov B M Spravochnik po Atomnoî i Molekulyarnoî Fizike (Reference Data on Atoms, Molecules, and Ions Physics, Moscow: Atomizdat, 1980) [Translated into English (Berlin: Springer-Verlag, 1985)]
  55. Stupochenko E V, Losev S A, Osipov A I Relaksatsionnye Protsessy v Udarnykh Volnakh (Relaxation Processes in Shock Waves, Moscow: Nauka, 1965) [Translated into English (New York: Springer-Verlag, 1967)]
  56. Gordiets B F, Osipov A I, Shelepin L A Kineticheskie Protsessy v Gazakh i Molekulyarnye Lazery (Kinetic Processes in Gases and Molecular Lasers, Moscow: Nauka, 1980) [Translated into English (New York: Gordon and Breach Science Publ., 1988)]
  57. Rubin A B Biofizika. Kniga 2 Biofizika Kletochnykh Protsessov (Biophysics. Book 2. Biophysics of Cellular Processes, Moscow: Vyssh. Shkola, 1987)
  58. Vol’kenshteîn M V Obshchaya Biofizika (General Biophysics, Moscow: Nauka, 1978)
  59. Kovarskiî V A et al. Neadiabaticheskie Perekhody v Sil’nom Élektromagnitnom Pole (Non-Adiabatic Transitions in Strong Electromagnetic Field, Kishinev: Shtiintsa, 1980)
  60. Gurvich A G, Gurvich L D Mitogeneticheskoe Izluchenie (Mitogenic Radiation, Moscow: Medgiz, 1945)
  61. Gurvich A G Izbrannye Trudy (Selected Works, Moscow: Meditsina, 1977)
  62. Konev S V, Lyskova G I, Nisel’baum G P Biofizika 11 361 (1966)
  63. Romanovskiî Yu M, Stepanova N V, Chernavskiî D S Matematicheskaya Biofizika (Mathematics in Biophysics, Moscow: Nauka, 1984)
  64. Petukhov V G, in Trudy Moskovskogo Obshchestva Ispytateleî Prirody T. 58 Biokhemilyuminestsentsiya (Proceedings of Moscow Society of Naturalists V.58 Biochemiluminescence, Moscow: Nauka, 1983) p. 210
  65. Buehler G A Proc. Natl. Acad. Sci. USA 89 8288 (1992)
  66. Alberts B et al. Molecular Biology of Cell Vol. 3 (New York: Garland Publishing Inc., 1983)
  67. Belintsev B N Fizicheskie Osnovy Biologicheskogo Formoobrazovaniya (Physical Basis of Bioformation, Moscow: Nauka, 1991)
  68. Witkin E M Bacteriol. Rev. 40 869 (1976)
  69. Kovarskiî V A, Profir A V Biofizika 33 758 (1988)
  70. Kovarskiî V A, Profir A V Mol. Biol. 31 454 (1997)
  71. Georgiev G P Mol. Biol. 4 17 (1970)
  72. Kovarskiî V A, Profir A V Biofizika 34 259 (1989) [Biophysics 34 277 (1989)]
  73. Ptashne M A Genetic Switch. Gene Control and Phage lambda (Cambridge, Mass.: Cell Press, 1986) [Translated into Russian (Moscow: Mir, 1988)]
  74. Kovarskiî V A, Profir A V Mol. Biol. 25 1293 (1991)
  75. Dubinin N P Potentsial’nye Izmeneniya v DNK i Mutatsii: Molekulyarnaya Tsitogenetika (Potential DNA Changes and Mutations: Molecular Cytogenetics, Moscow: Nauka, 1978)
  76. Pokosovskaya A V, Kovarskiî V A Dokl. Akad. Nauk SSSR 313 457 (1990)
  77. Hunter T, Seflon B M Proc. Natl. Acad. Sci. USA 77 1311 (1980)
  78. Dubinin N P Novoe v Sovremennoî Genetike (Recent Progress in Genetics, Moscow: Nauka, 1986)
  79. Georgiev G P Mol. Biol. 29 124 (1981)
  80. Jacob F, Monod J Molecular Biology. Problems and Prospects [Translated into Russian (Moscow: Nauka, 1964)]
  81. Chernavskiî D S, Grigorov L N, Polyakova M S Kolebatel’nye Protsessy v Biologicheskikh i Khimicheskikh Sistemakh (Vibrational Processes in Biological and Chemical Systems, Moscow: Nauka, 1967)
  82. Grigorov L N, Polyakova M S, Chernavskiî D S Mol. Biol. 1 410 (1967)
  83. Newsholme E A, Start C Regulation in Metabolism (New York: Wiley, 1973) [Translated into Russian (Moscow: Mir, 1977)]
  84. Severin E S, Kochetkova M N Rol’ Fosforilirovaniya v Regulyatsii Kletochnoî Aktivnosti (The Role of Phosphorylation in Cell Control, Moscow: Nauka, 1985)
  85. Blagoveshchenskiî A V Biokhimicheskaya Évolyutsiya Tsvetkovykh Rasteniî (Biochemical Evolution of Flowering Plants, Moscow: Nauka, 1966)
  86. Sozinov A A Polimorfizm Belkov i Ego Znachenie v Genetike i Selektsii (Protein Polymorphism and Its Implications for Genetics and Selection, Moscow: Nauka, 1985)
  87. Lewin B Genes (New York: John Wiley and Sons, 1983) [Translated into Russian (Moscow: Mir, 1987)]
  88. Shapiro J (Ed.) Mobile Genetic Elements (New York: Academic Press, 1983)
  89. Kunze R et al., in Proc. XVIth Conf. of the Eucarpia Maize and Sorghum Selection (Bergamo, Italy, 1993)
© 1918–2024 Uspekhi Fizicheskikh Nauk
Email: ufn@ufn.ru Editorial office contacts About the journal Terms and conditions