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Calcium oscillations in blood platelets and their possible role in extracellular information "interpretation" by cell

 a, b,  b,  c, b,  a, c, b,  a, c, b
a Lomonosov Moscow State University, Department of Physics, Vorobevy gory, Moscow, 119992, Russian Federation
b Center for Theoretical Problems of Physicochemical Pharmacology RAS, ul. Kosygina 4, Moscow, 119991, Russian Federation
c Federal Research Center of Pediatric Hematology, Oncology and Immunology, ul. Samory Mashela 1, Moscow, 117997, Russian Federation

Intracellular Ca2+ ions play a crucial role in extracellular signal transduction and analysis in a cell. When extracellular signals appear, the cell can increase intracellular Ca2+ concentration in hundreds of times in less than a second. This triggers different cellular systems, which lead to the desired cellular response. In a majority of cells, the extracellular signal appearance induces not only Ca2+ concentration elevation but also triggers Ca2+ concentration oscillations. Extracellular signal strength affects the frequency and amplitude of these oscillations. There are reasons to suppose that extracellular signal transformation in oscillating intracellular signal has an essential informational significance. In this review we will cover modern methods of Ca2+ dynamics measurement in the cell, mechanisms of oscillations formation, and articulate hypotheses regarding the oscillations decoding by the cell. The main object of our examination will be a platelet — a cell which plays a key role in bleeding prevention. When the vessel injury occurs, platelet promptly gets activated. In the process of stopping bleeding, initially the same platelets are divided into three populations, which play completely different roles. It seems that the platelet somehow "interprets" a set of external signals, and via the Ca2+ concentration oscillations it "chooses" the population to which it will belong. The relative simplicity of the platelet allows us to hope that the research of this cell will soon lead to the decoding of the "code" which hides behind the Ca2+ oscillations.

Text is available here.

Keywords: calcium oscillations, platelets, coding, decoding, Hopf bifurcation
DOI: 10.3367/UFNe.2018.05.038335
Citation: Shakhidzhanov S S, Balabin F A, Obydennyi S I, Ataullakhanov F I, Sveshnikova A N "Calcium oscillations in blood platelets and their possible role in extracellular information "interpretation" by cell" Phys. Usp., accepted

Received: 8th, May 2018, 10th, May 2018

Оригинал: Шахиджанов С С, Балабин Ф А, Обыденный С И, Атауллаханов Ф И, Свешникова А Н «Кальциевые осцилляции в тромбоцитах крови и их возможная роль в "интерпретации" клеткой информации из внешнего мира» УФН, принята к публикации; DOI: 10.3367/UFNr.2018.05.038335

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