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Methods of biomedical optical imaging: from subcellular structures to tissues and organs

Federal Research Center Institute of Applied Physics of the Russian Academy of Sciences, ul. Ulyanova 46, Nizhny Novgorod, 603000, Russian Federation

Optical bioimaging methods have a wide range of applications in life science, most notably including: the molecular resolution study of subcellular structures, the small animal molecular imaging, and the structural and functional clinical diagnostics of tissue layers and organs. In this paper, fluorescent microscopy, fluorescent macroscopy, optical coherence tomography, optoacoustic tomography and optical diffuse spectroscopy and tomography are reviewed from the standpoint of physical fundamentals, applications and progress.

Keywords: optical bioimaging, biophotonics, optical coherence tomography, fluorescent microscopy, optical nanoscopy, optoacoustics, optical diffusion tomography, fluorescent agents, fluorescent proteins, upconversion nanoparticles, STED, STORM
PACS: 42.25.Dd, 42.62.Be, 43.35.Sx, 87.64.−t, 87.64.Cc (all)
DOI: 10.3367/UFNe.2015.12.037734
Citation: Turchin I V "Methods of biomedical optical imaging: from subcellular structures to tissues and organs" Phys. Usp. 59 487–501 (2016)
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7th, December 2015

Оригинал: Турчин И В «Методы оптической биомедицинской визуализации: от субклеточных структур до тканей и органов» УФН 186 550–567 (2016); DOI: 10.3367/UFNr.2015.12.037734

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