Surface-enhanced Raman scattering and its application to the study of biological molecules

Work on surface-enhanced Raman scattering (RS) of light by molecules near a metal surface is reviewed. The experimental conditions for obtaining surface-enhanced Raman scattering spectra in different molecule-metal systems are examined. The basic characteristics and mechanisms of the effect are discussed. Special attention is devoted to applications of the method of surface-enhanced Raman scattering spectroscopy for structural-functional study of biological molecules: DNA, proteins, supramolecular complexes. It is pointed out that the large enhancement of the RS cross section makes it possible to reduce the concentration of the substances under study by three orders of magnitude--down to 10$^8$--10$^9$ M. The short range of the enhancement mechanism in some systems makes it possible to obtain Raman scattering spectra for groups of atoms located directly adjacent to the surface of the metal and thereby to study the topography of biological macromolecules and the kinetics of their behavior at an interface. The prospects for applications of enhanced Raman scattering as a new method of vibrational spectroscopy of biopolymers are discussed.

PACS: 87.15.Mi, 87.64.Je, 78.30.−j, 33.20.Fb (all)
DOI: 10.1070/PU1988v031n03ABEH005720
URL: https://ufn.ru/en/articles/1988/3/d/
Citation: Nabiev I R, Efremov R G, Chumanov G D "Surface-enhanced Raman scattering and its application to the study of biological molecules" Sov. Phys. Usp. 31 241–262 (1988)

BibTexBibNote ® (generic)BibNote ® (RIS)MedlineRefWorks

Оригинал: Набиев И Р, Ефремов Р Г, Чуманов Г Д «Гигантское комбинационное рассеяние и его применение к изучению биологических молекул» УФН 154 459–496 (1988); DOI: 10.3367/UFNr.0154.198803d.0459

References (168) Cited by (84) Similar articles (20) ↓

N.I. Koroteev “Interference phenomena in coherent active spectroscopy of light scattering and absorption: holographic multidimensional spectroscopy” Sov. Phys. Usp. 30 628–643 (1987)
I.B. Borovskii, R.V. Vedrinskii et al “EXAFS spectroscopy: a new method for structural investigation” Sov. Phys. Usp. 29 539–569 (1986)
A.B. Tolstoguzov, P.Yu. Babenko, A.N. Zinoviev “Surface analysis by low-energy ion scattering spectroscopy” Phys. Usp. 69 42–73 (2026)
A.N. Shalygin, K.A. Krotov “Magnetic capture of individual biological cells and model aggregates of cell membranes” Sov. Phys. Usp. 33 (7) 541–553 (1990)
V.A. Belyakov, V.E. Dmitrienko “Polarization phenomena in x-ray optics” Sov. Phys. Usp. 32 697–719 (1989)
R.Z. Bakhtizin, T. Hashizume et al “Atomic structures on a GaAs(001) surface grown by molecular beam epitaxy” Phys. Usp. 40 1175–1187 (1997)
N.M. Blashenkov, G.Ya. Lavrent’ev “Surface-ionization field mass-spectrometry studies of nonequilibrium surface ionization” Phys. Usp. 50 53–78 (2007)
V.N. Samofalov, D.P. Belozorov, A.G. Ravlik “Strong stray fields in systems of giant magnetic anisotropy magnets” Phys. Usp. 56 269–288 (2013)
S.S. Alimpiev, A.A. Grechnikov, S.M. Nikiforov “New approaches to the laser mass spectrometry of organic samples” Phys. Usp. 58 191–195 (2015)
E.N. Ragozin, E.A. Vishnyakov et al “Soft X-ray spectrometers based on aperiodic reflection gratings and their application” Phys. Usp. 64 495–514 (2021)
V.N. Ochkin “Spectroscopy of small gas components of a nonequilibrium low-temperature plasma” Phys. Usp. 65 1071–1103 (2022)
A.E. Ieshkin, A.B. Tolstoguzov et al “Gas-dynamic sources of cluster ions for basic and applied research” Phys. Usp. 65 677–705 (2022)
P.V. Zinin, K.M. Bulatov et al “Remote measurement of the temperature distribution on the surface of solids under high-power laser irradiation” Phys. Usp. 65 852–863 (2022)
S.A. Pshenichnyuk, N.L. Asfandiarov et al “State of the art in dissociative electron attachment spectroscopy and its prospects” Phys. Usp. 65 163–188 (2022)
A.I. Protsenko, I.A. Eliovich et al “Investigation of the dynamics of the Belousov—Zhabotinsky reaction by time-resolved X-ray absorption spectroscopy using adaptive X-ray optical elements” Phys. Usp. 66 1258–1261 (2023)
V.V. Lider “X-ray refraction introscopy” Phys. Usp. 67 325–337 (2024)
D.N. Klyshko, A.N. Penin “The prospects of quantum photometry” Sov. Phys. Usp. 30 716–723 (1987)
L.N. Rashkovich, O.A. Shustin “New optical interference methods for studying the kinetics of crystallization in solution” Sov. Phys. Usp. 30 280–283 (1987)
O.V. Kulagin, G.A. Pasmanik, A.A. Shilov “Amplification and phase conjugation of weak signals” Sov. Phys. Usp. 35 (6) 506–519 (1992)
V.I. Grafutin, E.P. Prokop’ev “Positron annihilation spectroscopy in materials structure studies” Phys. Usp. 45 59–74 (2002)

The list is formed automatically.