The basic physics of radiation blistering and exfoliation is described. Experimental results are reported on the dependence of blistering on the radiation dose, the ion energy, the bombardment temperature, and the target orientation. Data are reported on a synergetic effect on blistering during the simultaneous bombardment of the first wall of a fusion reactor by fast atoms of various isotopes of hydrogen and helium. Methods for reducing blistering are reported. A theory is derived for radiation blistering.